Bettini Silvia, Carraro Enrico, Pilatone Anna, Schiff Sami, Girardi Paolo, D'Angelo Matteo, Begolli Anxhela, Mansouri Fatemeh, Toosinezhad Saba, Sandri Sara, Gusella Beatrice, Milan Gabriella, Foletto Mirto, Fioretto Paola, Busetto Luca
Centre for the Study and the Integrated Treatment of Obesity, Department of Medicine, Padova University Hospital, 35128 Padova, Italy.
Department of Statistical Sciences, University of Padova, 35121 Padova, Italy.
Nutrients. 2025 Sep 8;17(17):2901. doi: 10.3390/nu17172901.
BACKGROUND/OBJECTIVES: A disruption of eating habits is related to obesity and obesity-related complications (ORCs), including diabetes and cardiovascular disease. We previously described chrono-nutritional profiles considering the eating habits of patients with severe obesity during the 24 h cycle. Our present study aims to determine, first, whether belonging to a specific eating profile is associated with greater or lesser weight loss in patients with obesity who have undergone bariatric surgery, and second, whether chrono-nutritional profiles are associated with the remission of ORCs after surgery. We also investigated whether there were differences between the original baseline profile and the new profile derived from the 24 h recall on dietary patterns.
The study included 75 patients with obesity who had undergone bariatric surgery and were followed up for a period of 36 ± 11 months. Data were collected from patients' medical records and telephone interviews. R software (v4.4.0; R Core Team, 2024) was used.
Significant weight loss from baseline was observed at follow-up for all profiles ( < 0.0001); however, there were no significant differences in weight loss % among profiles. Using a linear regression model, Profile 3 (characterized by irregular eating patterns) demonstrated less weight loss at follow-up compared to other profiles ( = 0.0487). There was a significant remission of ORCs from baseline to follow-up, but there were no significant differences among profiles.
Chrono-nutritional profiles may play a role in weight regulation in patients with severe obesity who are candidates for bariatric surgery. Further studies with a larger sample size are needed.
背景/目的：饮食习惯的紊乱与肥胖及肥胖相关并发症（ORC）有关，包括糖尿病和心血管疾病。我们之前描述了考虑严重肥胖患者24小时周期饮食习惯的时间营养概况。我们目前的研究旨在，首先确定属于特定的饮食概况是否与接受减肥手术的肥胖患者体重减轻的或多或少有关，其次确定时间营养概况是否与术后ORC的缓解有关。我们还调查了原始基线概况与通过24小时饮食模式回忆得出的新概况之间是否存在差异。
该研究纳入了75例接受减肥手术的肥胖患者，并进行了36±11个月的随访。数据从患者的病历和电话访谈中收集。使用了R软件（v4.4.0；R核心团队，2024）。
在随访时观察到所有概况的体重均较基线有显著减轻（<0.0001）；然而，各概况之间的体重减轻百分比没有显著差异。使用线性回归模型，概况3（以不规则饮食模式为特征）在随访时的体重减轻比其他概况少（=0.0487）。从基线到随访，ORC有显著缓解，但各概况之间没有显著差异。
时间营养概况可能在适合减肥手术的严重肥胖患者的体重调节中起作用。需要进行更大样本量的进一步研究。
