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[9,10-二甲基-1,2-苯并蒽与中枢神经系统毛细胞相互作用的特征]

[Characteristics of the interaction of 9,10-dimethyl-1,2-benzanthracene with the hairy cells in the central nervous system].

作者信息

Mardanova G V

出版信息

Biull Eksp Biol Med. 1977 Aug;84(8):197-9.

PMID:409443
Abstract

The implantation of a pill containing carcinogen DMBA into the right hemisphere of the rat brain induces the formation of a capsule, the innermost layer of which is composed of "hairy" cells. Two principally different mechanisms of carcinogen penetration into the "hairy" cell were distinguished: ordinary phagocytosis and biochemical interaction of carcinogen with the cell membrane. It is supposed that in the second case there occurs formation of secondary carcinogenic products in the form of steroid hormone which could be morphologically identified as lipid-like structures of the "hairy" cell.

摘要

将含有致癌物二甲基苯蒽(DMBA)的药丸植入大鼠脑右半球会诱导形成一个囊,其最内层由“毛状”细胞组成。区分出了致癌物进入“毛状”细胞的两种主要不同机制:普通吞噬作用以及致癌物与细胞膜的生化相互作用。据推测,在第二种情况下,会以类固醇激素的形式形成二级致癌产物,在形态上可将其识别为“毛状”细胞的类脂结构。

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