[7,12-二甲基-（α）-苯并蒽（DMBA）诱导大鼠乳腺癌变过程中腺垂体细胞RNA的细胞化学研究]
[Cytochemical study of the RNA in rat adenohypophysis cells during mammary carcinogenesis induced by 7-12-dimethyl-(a)-benzanthracene (DMBA)].
作者信息
Ganina K P, Iareshko A G
出版信息
Tsitol Genet. 1982;16(1):3-6.
PMID:6175060
Abstract
A cytochemical study of RNA was carried out in gonadotropic basophils and oxyphils of adenohypophysis of albino nonstrain rats during DMBA-induced mammary cancer growth. A stage character is found for changes in the RNA content depending on the mammary carcinogenesis phase. This shows that DMBA carcinogenic action besides a direct damage effect on the mammary gland is realized to a considerable extent through the endocrine system.
摘要
在二甲基苯并蒽（DMBA）诱导的白化非品系大鼠乳腺癌生长过程中，对其腺垂体促性腺嗜碱性细胞和嗜酸性细胞中的RNA进行了细胞化学研究。发现RNA含量的变化具有阶段特征，这取决于乳腺癌发生的阶段。这表明，DMBA的致癌作用除了对乳腺有直接损伤作用外，在很大程度上还通过内分泌系统得以实现。
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