老年人中氢化麦角碱的药代动力学。

Hydergine pharmacokinetics in the elderly.

作者信息

Lavène D, Humbert H, Kiechel J R, Ducreuzet C, Lajoie D, Guillevin L

出版信息

J Pharmacol. 1985;16 Suppl 3:135-43.

Abstract

The pharmacokinetics of Hydergine was studied following intramuscular administration in a group of 6 subjects aged 76-86 and following oral administration in 6 subjects aged 66-86. Comparison with a control group of healthy volunteers (average age of 25) showed: --a marked reduction (- 50%) in renal clearance (p less than 0.001), related to the decrease in creatinine clearance in this population; --a lowering (- 30%) in metabolic clearance (p less than 0.02) in elderly subjects probably related to the decrease in hepatic blood flow observed with age; --a marked increase in bioavailability (X 2.5) following oral administration in elderly subjects, due either to increased absorption, or to a decreased hepatic first-pass effect. These results underline the value of studying the kinetics of geriatric drugs in the target population.

摘要

对一组年龄在76 - 86岁的6名受试者进行肌肉注射后，以及对6名年龄在66 - 86岁的受试者进行口服给药后，研究了喜得镇的药代动力学。与一组健康志愿者（平均年龄25岁）对照组比较显示：——肾脏清除率显著降低（-50%）（p < 0.001），这与该人群中肌酐清除率的降低有关；——老年受试者代谢清除率降低（-30%）（p < 0.02），这可能与随年龄增长观察到的肝血流量减少有关；——老年受试者口服给药后生物利用度显著增加（2.5倍），这要么是由于吸收增加，要么是由于肝脏首过效应降低。这些结果强调了在目标人群中研究老年药物动力学的价值。