Deficits in cholinergic enzyme activities in septo-temporal regions of the senescent rat hippocampus, and in the forebrain of aged mice: effect of chronic Hydergine treatment.

Choline acetyltransferase and acetylcholinesterase activities in the septo-temporal regions of the rat hippocampus, and in the forebrain of mice were significantly decreased in senescent as compared with adult animals. A four week treatment of aged rats or mice with Hydergine resulted in the restoration of choline acetyltransferase activity.