Wang Zihao, Ling Na, Guo Chunqiu, Tian Haiyan, Gao Mingze, Li Wenlan, Ji Chenfeng
Pharmaceutical Engineering Technology Research Center, Harbin University of Commerce, Harbin 150076, China; Engineering Research Center for Natural Antitumor Drugs, Ministry of Education, Harbin University of Commerce, Harbin 150076, China.
Pharmaceutical Engineering Technology Research Center, Harbin University of Commerce, Harbin 150076, China; Engineering Research Center for Natural Antitumor Drugs, Ministry of Education, Harbin University of Commerce, Harbin 150076, China.
Phytomedicine. 2025 Nov;147:157219. doi: 10.1016/j.phymed.2025.157219. Epub 2025 Sep 4.
Inulin, a crucial component in Jerusalem artichoke (JAI), has drawn significant attention. It is not only a high - quality dietary fiber but also exhibits a spectrum of pharmacological functions, such as lowering blood glucose and blood lipids, regulating intestinal flora, immunoregulation and maintenance of gut homeostasis. The research of Jerusalem artichoke inulin in the realm of structure and bioactivities is of great significance.
This review comprehensively summarizes the latest advancements on the extraction, purification, structural characteristics, biological activities, structure-activity relationship and structural modification of Jerusalem artichoke inulin. It also elucidates the pharmacokinetics, safety assessment, as well as the potential application of JAI, offering invaluable insights for its development and utilization.
The extensive literatures were conducted compiling the information on the extraction, purification, structural characterization, structure-activity relationsip, structural modification, pharmacokinetics and safety assessment of Jerusalem artichoke inulin from diverse databases including PubMed, Web of Science, ScienceDirect and CNKI. This thorough summary lays the foundation for comprehensive understanding of JAI.
Jerusalem artichoke inulin, a key bioactive component, can be obtained through various extraction methods, especially hot water extraction, ultrasonic-assisted extraction, microwave-assisted extraction from the laboratory research to the large-scale production. Subsequently, a variety of analytical techniques such as GC-MS, HPLC, FT-IR, NMR are conducted to delve into the degree of polymerization, molecular weight, monosaccharide composition, glycosidic bond and chemical structure of inulin. Additionally, JAI possesses multifaceted bioactivities, including regulating gut microbiota, reducing blood glucose and lipids, enhancing immune, and promoting mineral absorption. Furthermore, the structure-activity relationship and structural modification of inulin are also highlighted, especially by chemical, physical, or biological modification to endow inulin with superior biological activities and physicochemical properties. The pharmacokinetics and safety assessment highlight its application in food, pharmaceuticals and biomedical industry.
This summary has laid a robust foundation for extracting inulin from Jerusalem artichoke and elucidating its structure characteristics and physicochemical properties. Moreover, a substantial evidence is also complemented to exhibit its multifaceted biological attributes, including the regulation of gut microbiota, immunomodulation, blood glucose-lowering and blood lipids-lowering, as well as the promotion of mineral absorption. Noteworthily, the structure-activity relationship and structural modification of JAI elucidates the intricate interactions between its molecular structure and dynamic host-microbiota. The pharmacokinetics and safety assessment emphasize its application in the fields of food and pharmaceuticals.
菊粉是菊芋中的关键成分，已引起广泛关注。它不仅是一种优质膳食纤维，还具有一系列药理功能，如降低血糖和血脂、调节肠道菌群、免疫调节以及维持肠道稳态。菊芋菊粉在结构和生物活性领域的研究具有重要意义。
本综述全面总结了菊芋菊粉在提取、纯化、结构特征、生物活性、构效关系和结构修饰方面的最新进展。还阐明了菊芋菊粉的药代动力学、安全性评估以及潜在应用，为其开发利用提供了宝贵见解。
从包括PubMed、Web of Science、ScienceDirect和CNKI在内的多个数据库中收集关于菊芋菊粉提取、纯化、结构表征、构效关系、结构修饰、药代动力学和安全性评估的信息，并对大量文献进行整理。这一全面总结为全面了解菊芋菊粉奠定了基础。
菊芋菊粉作为一种关键的生物活性成分，可通过多种提取方法获得，尤其是从实验室研究到大规模生产的热水提取、超声辅助提取、微波辅助提取。随后，采用多种分析技术，如气相色谱 - 质谱联用（GC-MS）、高效液相色谱（HPLC）、傅里叶变换红外光谱（FT-IR）、核磁共振（NMR），深入研究菊粉的聚合度、分子量、单糖组成、糖苷键和化学结构。此外，菊芋菊粉具有多方面的生物活性，包括调节肠道微生物群、降低血糖和血脂、增强免疫力以及促进矿物质吸收。此外，还重点介绍了菊粉的构效关系和结构修饰，特别是通过化学、物理或生物修饰赋予菊粉优异的生物活性和理化性质。药代动力学和安全性评估突出了其在食品、制药和生物医学行业的应用。
本综述为从菊芋中提取菊粉并阐明其结构特征和理化性质奠定了坚实基础。此外，还补充了大量证据以展示其多方面的生物学特性，包括调节肠道微生物群、免疫调节、降低血糖和血脂以及促进矿物质吸收。值得注意的是，菊芋菊粉的构效关系和结构修饰阐明了其分子结构与动态宿主 - 微生物群之间的复杂相互作用。药代动力学和安全性评估强调了其在食品和制药领域的应用。
