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共同决策后短效脊髓麻醉和全身麻醉后的术后谵妄

Postoperative delirium after short-acting spinal anesthesia and general anesthesia after shared decision-making.

作者信息

Kipping Valesca, Kerlin Timo B, Borchers Friedrich, Külken Margret F, Schmid Marilena, Ahrend Christopher S, Wiebach Janine, Piper Sophie K, Wernecke Klaus D, Müller Anika, Spies Claudia D

机构信息

Department of Anesthesiology and Intensive Care Medicine, Charité - Universitätsmedizin Berlin, Germany.

Berlin Institute of Health at Charité - Universitätsmedizin Berlin, BIH Metabolomics, Germany.

出版信息

J Int Med Res. 2025 Sep;53(9):3000605251363408. doi: 10.1177/03000605251363408. Epub 2025 Sep 13.

Abstract

ObjectivePrevious studies have shown that the postoperative delirium rate does not differ between anesthetic techniques in randomized controlled trials. Subjective concerns such as anxiety and pain are often not adequately addressed in randomized controlled trials and reported to be associated with postoperative delirium. Shared decision-making is reported to have an impact on anxiety and pain. Therefore, the aim of this study was to evaluate the effect of shared decision-making while making a choice between spinal and general anesthesia on postoperative delirium incidence.MethodsThis prospective, observational, two-armed cohort study included 192 patients who underwent lower extremity, lower abdominal, pelvic, or perineal short-time surgery that lasted <90 min. The three-talk shared decision-making model was used to make the choice for the type of anesthesia. Depending on the shared decision-making process, either spinal anesthesia with short-acting local anesthetics (prilocaine hydrochloride or chloroprocaine hydrochloride) or general anesthesia was performed according to a standardized protocol including intraoperative electroencephalogram monitoring. Patients' anxiety and pain levels were measured before and after the surgery using validated scales.ResultsBased on their shared decision-making choice of anesthesia, 97 patients were allocated to the spinal anesthesia group and 95 to the general anesthesia group. Postoperative delirium occurred less frequently after spinal anesthesia (2.1%) than after general anesthesia (16.8%; p < 0.001). No postoperative delirium was observed in patients who received only spinal anesthesia, as chosen using the shared decision-making model (spinal anesthesia: 0%, general anesthesia 16.8%; p < 0.001). Anxiety and pain levels did not differ between the two groups.ConclusionsThe incidence of postoperative delirium was lower in patients who were administered spinal anesthesia than in those who were administered general anesthesia after using a shared decision-making approach. Integrating patients' perspectives and treatment preferences might change postoperative outcomes and should be taken into consideration in future trials. clinicaltrials.gov: NCT03715244https://clinicaltrials.gov/study/NCT03715244?intr=NCT03715244&rank=1.

摘要

目的

以往研究表明,在随机对照试验中,不同麻醉技术的术后谵妄发生率并无差异。随机对照试验往往未能充分解决焦虑和疼痛等主观问题,且这些问题被认为与术后谵妄有关。据报道,共同决策对焦虑和疼痛有影响。因此,本研究旨在评估在腰麻和全麻之间进行选择时,共同决策对术后谵妄发生率的影响。

方法

这项前瞻性、观察性、双臂队列研究纳入了192例接受下肢、下腹部、盆腔或会阴短时间手术(手术时长<90分钟)的患者。采用三谈话共同决策模型来选择麻醉类型。根据共同决策过程,按照包括术中脑电图监测的标准化方案,采用短效局麻药(盐酸丙胺卡因或盐酸氯普鲁卡因)进行腰麻或全麻。使用经过验证的量表在手术前后测量患者的焦虑和疼痛水平。

结果

根据他们对麻醉的共同决策选择,97例患者被分配到腰麻组,95例被分配到全麻组。腰麻后术后谵妄的发生率(2.1%)低于全麻后(16.8%;p<0.001)。在使用共同决策模型选择仅接受腰麻的患者中未观察到术后谵妄(腰麻:0%,全麻16.8%;p<0.001)。两组之间的焦虑和疼痛水平无差异。

结论

采用共同决策方法后,接受腰麻的患者术后谵妄发生率低于接受全麻的患者。纳入患者的观点和治疗偏好可能会改变术后结果,未来的试验应予以考虑。

临床试验.gov:NCT03715244

https://clinicaltrials.gov/study/NCT03715244?intr=NCT03715244&rank=1

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b552/12433544/41ed4d512229/10.1177_03000605251363408-fig1.jpg

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