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[异动症作为帕金森病左旋多巴治疗的并发症——临床观察]

[Dyskinesia as a complication of the treatment of Parkinson disease with L-dopa--clinical observations].

作者信息

Friedman A

出版信息

Neurol Neurochir Pol. 1985 Jul-Aug;19(4):291-4.

PMID:4094640
Abstract

The incidence of drug-induced dyskineses was evaluated in a group of 131 patients with Parkinson's disease on long-term treatment with L-DOPA preparations and the relationships were sought for between this incidence, and age of the patient at the onset of the disease and duration of treatment. Drug-induced dyskineses were observed in 79 (60%) patients. It was observed that their incidence was greater in patients with disease onset at a younger age. The mean age of disease onset in cases with dyskinesis development was nearly 10 years lower than the mean age of disease onset in those who had no dyskineses. In most cases of dyskinesis it developed already in the first year of treatment.

摘要

对一组131例长期接受左旋多巴制剂治疗的帕金森病患者的药物性运动障碍发生率进行了评估,并探讨了该发生率与疾病发病时患者年龄及治疗持续时间之间的关系。79例(60%)患者出现了药物性运动障碍。观察到发病年龄较轻的患者中其发生率更高。出现运动障碍的患者的疾病平均发病年龄比未出现运动障碍的患者的疾病平均发病年龄低近10岁。在大多数运动障碍病例中,其在治疗的第一年就已出现。

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