输注全氟碳血液代用品的大鼠体内的共轭儿茶酚胺

Conjugated catecholamines in rats transfused with perfluorocarbon blood substitute.

作者信息

Wilson J X, West N H, Amies M, Michalska E

出版信息

Neurosci Lett. 1985 Dec 18;62(3):329-33. doi: 10.1016/0304-3940(85)90570-1.

Abstract

The reappearance of circulating catecholamines (CAs) after transfusion with perfluorocarbon blood substitute and the importance of blood for CA conjugation were determined in rats. Arterial plasma concentrations of unconjugated (i.e. free), sulfoconjugated and glucuronoconjugated forms of the CAs dopamine (DA), noradrenaline (NA) and adrenaline (AD) in cannulated, anesthetized, control rats remained stable during the 4.5 h long experiments. Contrarily, in parallel experiments with another group of rats, replacement of blood by the perfluorocarbon blood substitute initially lowered the arterial concentrations of DA glucuronide, free AD and AD glucuronide; subsequently, free DA, NA and AD increased, followed by delayed increases in conjugated CA levels. These changes in CA concentrations preceded a fall in systemic arterial blood pressure (pa) and thus were not the consequences of hypotension.

摘要

在大鼠中测定了输注全氟化碳血液代用品后循环儿茶酚胺（CAs）的再现情况以及血液对CA结合的重要性。在长达4.5小时的实验过程中，插管麻醉的对照大鼠动脉血浆中未结合（即游离）、硫酸结合和葡萄糖醛酸结合形式的儿茶酚胺多巴胺（DA）、去甲肾上腺素（NA）和肾上腺素（AD）的浓度保持稳定。相反，在另一组大鼠的平行实验中，用全氟化碳血液代用品替代血液最初降低了DA葡萄糖醛酸、游离AD和AD葡萄糖醛酸的动脉浓度；随后，游离DA、NA和AD增加，接着结合CA水平延迟升高。CA浓度的这些变化先于体循环动脉血压（pa）下降，因此不是低血压的后果。