Gong Xun, Ye Qing, Zhang Wenliang, Shen Yanan, Cao Zeng, Dun Yaoshan, Liu Suixin
Division of Cardiac Rehabilitation, Department of Physical Medicine & Rehabilitation, Xiangya Hospital, Central South University, Changsha, Hunan, China.
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Ann Med. 2025 Dec;57(1):2558124. doi: 10.1080/07853890.2025.2558124. Epub 2025 Sep 15.
This study evaluated the effectiveness of Xiangya Hospital Circuit Training (X-CircuiT), a multi-component exercise program, as an alternative to conventional exercise (ConEx) in improving cardiorespiratory and muscular fitness within home-based cardiac rehabilitation (HBCR) for patients with coronary artery disease and risk factors (CADRF).
This randomized controlled non-inferiority trial consecutively enrolled patients with CADRF at Xiangya Hospital, China, between April and December 2020. Patients were assigned to a smartphone-guided X-CircuiT-HBCR or telephone call-guided ConEx-HBCR group for 12 weeks. Primary outcomes were cardiorespiratory fitness (peak oxygen uptake, Opeak), and muscular fitness (30-sec arm curl and chair stand tests). The non-inferiority margins were 2.17 mL/kg/min, 2.70 reps, and 1.23 reps, respectively. Secondary outcomes included O pulse, O at ventilatory threshold, balance, flexibility, body mass index, health-related quality of life (HRQoL), self-efficacy, physical activity, safety, and exercise adherence.
This trial included 54 participants (median age 53 yr, 37% females), with 27 per group. Both groups showed significant improvements in fitness. There were no significant differences between groups in the improvements in Opeak (mean difference, -0.13 [95%CI, -1.76 to 1.50] mL/kg/min), arm curl test (0.21 [-1.35 to 1.77] reps), and chair stand test (1.30 [-0.18 to 2.77] reps), with 95% CIs within the non-inferiority range. No significant differences were found in HRQoL, self-efficacy, and exercise adherence (all > .05). No adverse events occurred.
X-CircuiT is non-inferior to ConEx in HBCR for CADRF patients, suggesting it as an effective alternative or supplement in HBCR programs.
ChiCTR2000032451.
本研究评估了湘雅医院循环训练（X-CircuiT）这一多组分运动计划，作为传统运动（ConEx）的替代方案，在居家心脏康复（HBCR）中改善冠心病及危险因素（CADRF）患者心肺和肌肉适能的效果。
这项随机对照非劣效性试验于2020年4月至12月在中国湘雅医院连续纳入CADRF患者。患者被分配至智能手机引导的X-CircuiT-HBCR组或电话引导的ConEx-HBCR组，为期12周。主要结局为心肺适能（峰值摄氧量，Opeak）和肌肉适能（30秒臂弯举和坐立试验）。非劣效界值分别为2.17 mL/kg/min、2.70次重复和1.23次重复。次要结局包括静息心率、通气阈值时心率、平衡能力、柔韧性、体重指数、健康相关生活质量（HRQoL）、自我效能感、身体活动、安全性和运动依从性。
本试验纳入54名参与者（中位年龄53岁，37%为女性），每组27人。两组的适能均有显著改善。两组在Opeak改善（平均差异，-0.13 [95%CI，-1.76至1.50] mL/kg/min）、臂弯举试验（0.21 [-1.35至1.77]次重复）和坐立试验（1.30 [-0.18至2.77]次重复）方面无显著差异，95%CI在非劣效范围内。在HRQoL、自我效能感和运动依从性方面均未发现显著差异（均P>.05）。未发生不良事件。
对于CADRF患者，X-CircuiT在HBCR中不劣于ConEx，表明它是HBCR计划中一种有效的替代或补充方案。
ChiCTR2000032451。
