Strauss A A, Modanlou H D, Komatsu G
Pediatr Pharmacol (New York). 1985;5(3):209-12.
A case of parent-induced theophylline toxicity in a preterm infant is described. Despite a theophylline level of 97 mcg/ml no clinical seizure activity was apparent. Pharmacokinetic data suggested that use of oral activated charcoal may have enhanced drug clearance. Further study is necessary before such therapy can be routinely advocated. Additional clinical features are discussed, including avoidance of dosing errors through careful instruction of all caretakers prior to discharge.
本文描述了一例因家长给药导致的早产儿茶碱中毒病例。尽管茶碱水平达到了97微克/毫升，但未出现明显的临床癫痫活动。药代动力学数据表明，口服活性炭可能提高了药物清除率。在这种治疗方法能够被常规推荐之前，有必要进行进一步研究。文中还讨论了其他临床特征，包括在出院前对所有护理人员进行仔细指导以避免给药错误。
