Sohn Sang-June, Lim Sohee, Park Junghoon, Choi Ulsoo, Hong Yeon-Jung
Western Referral Animal Medical Center, Seoul, Republic of Korea.
College of Veterinary Medicine, Jeonbuk National University, Iksan, Republic of Korea.
Front Vet Sci. 2025 Aug 26;12:1636725. doi: 10.3389/fvets.2025.1636725. eCollection 2025.
Paragangliomas are rare neuroendocrine tumors arising from paraganglionic tissues associated with the autonomic nervous system. Although they are uncommon in veterinary medicine, particularly in cats, accurate diagnosis is essential due to their potential malignancy. An 18-month-old neutered male domestic shorthair cat presented with a retroperitoneal mass near adrenal glands. Computed tomography revealed an irregular, mildly contrast-enhancing mass abutting both adrenal glands and displacing adjacent vessels. Fine-needle aspiration cytology suggested a malignant round cell tumor with differential diagnosis of lymphoma, nephroblastoma, or primary embryonal tumor. Surgical excision was performed and histopathological examination identified a high-grade round cell neoplasm with a high mitotic index. A broad panel of immunohistochemistry excluded lymphoma and nephroblastoma, confirming extra-adrenal paraganglioma based on strong positivity for anti-synaptophysin, neuron-specific enolase, chromogranin A, and cytokeratin 19 antibodies. On postoperative day two, the cat developed suspected cranial mesenteric artery thrombosis leading to mesenteric ischemia and eventually euthanasia due to poor prognosis. This case emphasizes the importance of considering extra-adrenal paraganglioma in differential diagnoses of retroperitoneal masses in young cats and highlights the critical role of advanced imaging and immunohistochemistry in achieving definitive diagnosis.
副神经节瘤是起源于与自主神经系统相关的副神经节组织的罕见神经内分泌肿瘤。尽管它们在兽医学中并不常见，尤其是在猫身上，但由于其潜在的恶性程度，准确诊断至关重要。一只18个月大的绝育雄性家养短毛猫出现肾上腺附近的腹膜后肿块。计算机断层扫描显示一个不规则的、轻度强化的肿块，毗邻双侧肾上腺并推移相邻血管。细针穿刺细胞学检查提示为恶性圆形细胞瘤，鉴别诊断包括淋巴瘤、肾母细胞瘤或原发性胚胎性肿瘤。进行了手术切除，组织病理学检查发现一个有高有丝分裂指数的高级别圆形细胞瘤。一系列广泛的免疫组织化学检查排除了淋巴瘤和肾母细胞瘤，基于抗突触素、神经元特异性烯醇化酶、嗜铬粒蛋白A和细胞角蛋白19抗体的强阳性确诊为肾上腺外副神经节瘤。术后第二天，这只猫出现疑似肠系膜上动脉血栓形成，导致肠系膜缺血，最终因预后不良而实施安乐死。该病例强调了在幼猫腹膜后肿块的鉴别诊断中考虑肾上腺外副神经节瘤的重要性，并突出了先进影像学和免疫组织化学在实现明确诊断中的关键作用。
