Leonardi Leonardo, Rizac Raluca Ioana, Pettinari Ilaria, Mechelli Luca, De Feo Carlo
Department of Veterinary Medicine, University of Perugia, Via San Costanzo, 4-06126 Perugia, Italy.
Faculty of Veterinary Medicine, University of Agronomic Sciences and Veterinary Medicine of Bucharest, 105 Splaiul Independentei-District 5, 050097 Bucharest, Romania.
Vet Sci. 2021 May 14;8(5):86. doi: 10.3390/vetsci8050086.
Paraganglioma is a rare neuroendocrine neoplasm originating from paraganglia and consisting of neuroendocrine cells of the sympathetic and parasympathetic nervous system. Extra-adrenal paraganglioma occurs with a low incidence in both humans and animals. This report presents the first case of paraganglioma in a cat with orbital primary location. An 18-year-old spayed female European domestic shorthair cat of 3.60 kg body weight was evaluated in a private veterinary clinic in Perugia, Italy, for a pronounced exophthalmos of the right eye. The cat underwent surgery for the enucleation of the right eye and of the mass. The biopsy samples of the removed tissue were fixed in 10% buffered neutral formalin for histological and immunohistochemical evaluations. Therefore, specific markers were used for immunohistochemical investigations, such as anti-neuron specific enolase (NSE), anti-synaptophysin, anti-glial fibrillary acid protein, anti-cytokeratin and anti-chromogranin. The results of these investigations allowed establishing the final diagnosis of ocular extra-adrenal paraganglioma of the cat.
副神经节瘤是一种罕见的神经内分泌肿瘤，起源于副神经节，由交感神经系统和副交感神经系统的神经内分泌细胞组成。肾上腺外副神经节瘤在人类和动物中的发病率都很低。本报告介绍了首例眼眶原发性猫副神经节瘤病例。一只18岁、体重3.60千克的绝育雌性欧洲家猫，因右眼明显眼球突出，在意大利佩鲁贾的一家私人兽医诊所接受评估。这只猫接受了右眼和肿物摘除手术。切除组织的活检样本用10%缓冲中性福尔马林固定，用于组织学和免疫组织化学评估。因此，使用了特定标记物进行免疫组织化学研究，如抗神经元特异性烯醇化酶（NSE）、抗突触素、抗胶质纤维酸性蛋白、抗细胞角蛋白和抗嗜铬粒蛋白。这些研究结果最终确诊了这只猫的眼肾上腺外副神经节瘤。
