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Positioning amivantamab and lazertinib in the therapeutic sequence for -mutant NSCLC: insights from CHRYSALIS-2 cohort A.

作者信息

Abodunrin Faith, Berlin Dillon E, Bestvina Christine M

机构信息

Section of Hematology/Oncology, Division of Medicine, University of Chicago Medicine, Chicago, IL, USA.

出版信息

Transl Lung Cancer Res. 2025 Aug 31;14(8):2906-2911. doi: 10.21037/tlcr-2025-461. Epub 2025 Aug 14.

DOI:10.21037/tlcr-2025-461
PMID:40948857
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12432654/
Abstract
摘要

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本文引用的文献

1
Preventing Infusion-Related Reactions With Intravenous Amivantamab-Results From SKIPPirr, a Phase 2 Study: A Brief Report.使用静脉注射氨万他单抗预防输液相关反应——SKIPPirr 2期研究结果:简要报告
J Thorac Oncol. 2025 Jun;20(6):809-816. doi: 10.1016/j.jtho.2025.01.018. Epub 2025 Jan 24.
2
Results from a phase Ib study of telisotuzumab vedotin in combination with osimertinib in patients with c-Met protein-overexpressing, EGFR-mutated locally advanced/metastatic non-small-cell lung cancer (NSCLC) after progression on prior osimertinib.替雷利珠单抗(telisotuzumab vedotin)联合奥希替尼用于先前奥希替尼治疗进展后的c-Met蛋白过表达、EGFR突变的局部晚期/转移性非小细胞肺癌(NSCLC)患者的Ib期研究结果。
Ann Oncol. 2025 May;36(5):583-591. doi: 10.1016/j.annonc.2025.01.001. Epub 2025 Jan 11.
3
Datopotamab Deruxtecan in Advanced or Metastatic Non-Small Cell Lung Cancer With Actionable Genomic Alterations: Results From the Phase II TROPION-Lung05 Study.达波妥单抗德鲁替康用于治疗具有可操作基因组改变的晚期或转移性非小细胞肺癌:II期TROPION-Lung05研究结果
J Clin Oncol. 2025 Apr;43(10):1254-1265. doi: 10.1200/JCO-24-01349. Epub 2025 Jan 6.
4
Amivantamab Plus Lazertinib in Patients With EGFR-Mutant NSCLC After Progression on Osimertinib and Platinum-Based Chemotherapy: Results From CHRYSALIS-2 Cohort A.奥希替尼和铂类化疗进展后,埃万妥单抗联合拉泽替尼治疗表皮生长因子受体(EGFR)突变的非小细胞肺癌(NSCLC)患者:CHRYSALIS-2队列A的结果
J Thorac Oncol. 2025 May;20(5):651-664. doi: 10.1016/j.jtho.2024.12.029. Epub 2025 Jan 2.
5
Advancements in fourth-generation EGFR TKIs in EGFR-mutant NSCLC: Bridging biological insights and therapeutic development.第四代表皮生长因子受体酪氨酸激酶抑制剂在表皮生长因子受体突变型非小细胞肺癌中的进展:连接生物学见解和治疗开发。
Cancer Treat Rev. 2024 Nov;130:102824. doi: 10.1016/j.ctrv.2024.102824. Epub 2024 Sep 4.
6
Phase III KEYNOTE-789 Study of Pemetrexed and Platinum With or Without Pembrolizumab for Tyrosine Kinase Inhibitor‒Resistant, -Mutant, Metastatic Nonsquamous Non-Small Cell Lung Cancer.帕博利珠单抗联合培美曲塞和铂类对比培美曲塞和铂类用于治疗 EGFR/ALK 抑制剂耐药、突变的转移性非鳞状非小细胞肺癌的 III 期 KEYNOTE-789 研究
J Clin Oncol. 2024 Dec;42(34):4029-4039. doi: 10.1200/JCO.23.02747. Epub 2024 Aug 22.
7
Amivantamab plus Lazertinib in Previously Untreated -Mutated Advanced NSCLC.Amivantamab 联合 Lazertinib 治疗未经治的 - 突变型晚期 NSCLC。
N Engl J Med. 2024 Oct 24;391(16):1486-1498. doi: 10.1056/NEJMoa2403614. Epub 2024 Jun 26.
8
Subcutaneous Versus Intravenous Amivantamab, Both in Combination With Lazertinib, in Refractory Epidermal Growth Factor Receptor-Mutated Non-Small Cell Lung Cancer: Primary Results From the Phase III PALOMA-3 Study.皮下注射与静脉注射 Amivantamab,均联合 Lazertinib,治疗难治性表皮生长因子受体突变型非小细胞肺癌:III 期 PALOMA-3 研究的主要结果。
J Clin Oncol. 2024 Oct 20;42(30):3593-3605. doi: 10.1200/JCO.24.01001. Epub 2024 Jun 10.
9
Ivonescimab Plus Chemotherapy in Non-Small Cell Lung Cancer With EGFR Variant: A Randomized Clinical Trial.伊伏尼塞单抗联合化疗治疗 EGFR 突变型非小细胞肺癌的随机临床试验。
JAMA. 2024 Aug 20;332(7):561-570. doi: 10.1001/jama.2024.10613.
10
Nivolumab Plus Chemotherapy in Epidermal Growth Factor Receptor-Mutated Metastatic Non-Small-Cell Lung Cancer After Disease Progression on Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors: Final Results of CheckMate 722.纳武利尤单抗联合化疗治疗表皮生长因子受体突变型转移性非小细胞肺癌:表皮生长因子受体酪氨酸激酶抑制剂治疗进展后的 CheckMate 722 最终结果。
J Clin Oncol. 2024 Apr 10;42(11):1252-1264. doi: 10.1200/JCO.23.01017. Epub 2024 Jan 22.