El-Aghbary Dekra Ali, Thabet Rashad Ali, Almorish Mohammed A W, AlSayaghi Khaled Mohammed, Elkhalifa Ahmed M E
Department of Medical Microbiology and Immunology, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a, Yemen.
Department of Biochemistry, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a, Yemen.
Diabetes Metab Syndr Obes. 2025 Sep 9;18:3403-3414. doi: 10.2147/DMSO.S535445. eCollection 2025.
Obesity is a critical public health issue, marked by an accumulation of adipose tissue that presents numerous health hazards, with recent focus on the link between obesity and inflammation, especially in the context of inflammatory biomarkers as indicators of metabolic abnormalities related to obesity.
This study aimed to investigate the correlation between inflammatory biomarkers such as C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and hematological indicators of inflammation with anthropometric obesity measures in obese and non-obese healthy adults.
The study employed a case control design involving both obese and non-obese healthy adults. The research evaluated anthropometric indicators. Blood samples were collected from participants to measure complete blood count (CBC), CRP and ESR. Platelet /Lymphocyte ratio (PLR), Neutrophil/Lymphocyte ratio (NLR), Monocyte/Lymphocyte ratio (MLR), and the systemic immune-inflammation index (SII) were calculated.
A significant association exists between familial obesity, lack of physical activity, and constipation persistence in obese individuals compared to non-obese individuals. In the obese cohort, mean values of white blood cells (TWBCs), neutrophils, monocytes, platelet count, NLR, PLR, MLR, and SII were elevated compared to the non-obese group. Statistically significant differences in ESR and CRP were noted between the two populations. A positive correlation exists between TWBCs and WHR, whereas lymphocytes correlate positively with WHR and negatively with body fat percentage. Eosinophils exhibited negative associations with obesity metrics, while ESR and CRP had significant positive correlations with obesity indicators like BMI and body fat percentage; PLR showed a negative relationship with WHR and a positive one with body fat percentage, lacking significant correlations with BMI, WC, HC, or abdominal obesity.
The research indicates significant elevations in hematological biomarkers among obese individuals, highlighting a probable link between obesity and inflammation, with specific inflammatory markers potentially serving as predictors of obesity-related health risks.
肥胖是一个关键的公共卫生问题，其特征是脂肪组织堆积，存在众多健康危害，近期重点关注肥胖与炎症之间的联系，尤其是在炎症生物标志物作为与肥胖相关代谢异常指标的背景下。
本研究旨在调查肥胖和非肥胖健康成年人中炎症生物标志物如C反应蛋白（CRP）、红细胞沉降率（ESR）以及炎症血液学指标与人体测量肥胖指标之间的相关性。
该研究采用病例对照设计，纳入肥胖和非肥胖健康成年人。研究评估了人体测量指标。从参与者采集血样以测量全血细胞计数（CBC）、CRP和ESR。计算血小板/淋巴细胞比率（PLR）、中性粒细胞/淋巴细胞比率（NLR）、单核细胞/淋巴细胞比率（MLR）和全身免疫炎症指数（SII）。
与非肥胖个体相比，肥胖个体中家族性肥胖、缺乏身体活动和便秘持续存在之间存在显著关联。在肥胖队列中，与非肥胖组相比，白细胞（TWBC）、中性粒细胞、单核细胞、血小板计数、NLR、PLR、MLR和SII的平均值升高。两组人群的ESR和CRP存在统计学显著差异。TWBC与腰臀比（WHR）呈正相关，而淋巴细胞与WHR呈正相关，与体脂百分比呈负相关。嗜酸性粒细胞与肥胖指标呈负相关，而ESR和CRP与BMI和体脂百分比等肥胖指标呈显著正相关；PLR与WHR呈负相关，与体脂百分比呈正相关，与BMI、腰围（WC）、臀围（HC）或腹部肥胖无显著相关性。
研究表明肥胖个体的血液学生物标志物显著升高，突出了肥胖与炎症之间可能的联系，特定炎症标志物可能作为肥胖相关健康风险的预测指标。
