McLean LaToya, Andrews Carrie, Cappelli Louis, Gillan Grant, Curtis Mark, Evans James J, Shi Wenyin
Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
Department of Neurological Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
Case Rep Neurol Med. 2025 Sep 4;2025:6895334. doi: 10.1155/crnm/6895334. eCollection 2025.
We present a rare case of a collision tumor involving a pituitary macroadenoma and adamantinomatous craniopharyngioma in a 49-year-old woman. The patient presented with a 2-year history of amenorrhea and elevated prolactin. Brain MRI revealed two sellar masses. Initially managed with observation due to the absence of neurological deficits, surgical resection was later performed after clinical and radiographic progression. Pathology confirmed both tumor types: pituitary macroadenoma and adamantinomatous craniopharyngioma. Postoperative MRI showed residual disease at the superior margin. The patient subsequently received fractionated stereotactic radiation for residual disease and tolerated well.
我们报告了一例罕见的碰撞瘤病例，该病例发生在一名49岁女性身上，涉及垂体大腺瘤和造釉细胞瘤性颅咽管瘤。患者有2年闭经和催乳素升高病史。脑部磁共振成像（MRI）显示蝶鞍区有两个肿块。最初因无神经功能缺损而采取观察治疗，后来在临床和影像学进展后进行了手术切除。病理证实了两种肿瘤类型：垂体大腺瘤和造釉细胞瘤性颅咽管瘤。术后MRI显示上缘有残留病灶。患者随后接受了分次立体定向放射治疗残留病灶，耐受性良好。
