Huang Xiao-Rui, Zhu Deng-Sheng, Yu Ya-Hong
Department of Biliopancreatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, Hubei Province, China.
World J Gastrointest Surg. 2025 Aug 27;17(8):108767. doi: 10.4240/wjgs.v17.i8.108767.
Intraductal papillary mucinous neoplasm (IPMN) and intraductal papillary neoplasm of the bile duct (IPNB) are mucinous cystic tumors with intraductal papillary growth and malignant potential. Their concurrent occurrence is exceptionally rare.
A 58-year-old Chinese man presented with recurrent upper abdominal pain. Imaging and laboratory tests revealed lesions consistent with IPNB and IPMN. Postoperative pathological examination confirmed IPNB with high-grade dysplasia and main-duct type IPMN with low-grade dysplasia. The patient underwent extrahepatic bile duct resection with Roux-en-Y choledochoenterostomy and distal pancreatectomy. He had an excellent prognosis with no tumor recurrence during the 30-month follow-up.
This case emphasizes the importance of comprehensive preoperative assessment and individualized management for these complex tumors. Further research is needed to understand their pathogenesis and improve treatment strategies.
导管内乳头状黏液性肿瘤（IPMN）和胆管内乳头状肿瘤（IPNB）是具有导管内乳头状生长和恶性潜能的黏液性囊性肿瘤。它们同时发生极为罕见。
一名58岁中国男性因反复上腹部疼痛就诊。影像学和实验室检查发现病变符合IPNB和IPMN。术后病理检查确诊为高级别异型增生的IPNB和低级别异型增生的主胰管型IPMN。患者接受了肝外胆管切除、Roux-en-Y胆管空肠吻合术和远端胰腺切除术。在30个月的随访期间，他预后良好，无肿瘤复发。
该病例强调了对这些复杂肿瘤进行全面术前评估和个体化管理的重要性。需要进一步研究以了解其发病机制并改进治疗策略。
