Shahzad Muhammad, Maryam Kanz Ul Eman, Hashim Ali, Khan Amna Zaman, Ali Muhammad Abdullah, Khan Ahmed Yar, Younas Muhammad, Bokhari Syeda Sundus Shah, Khalid Wania, Shahzad Farah, Zia Kashmala, Hassan Ali, Niazi Muhammad Uzair Khan, Rahman Fahad, Waqas Saad Ahmed, Ahmed Raheel
Foundation University Medical College Islamabad Pakistan.
Al-Aleem Medical College University of Health Sciences Lahore Pakistan.
JGH Open. 2025 Sep 12;9(9):e70267. doi: 10.1002/jgh3.70267. eCollection 2025 Sep.
Vascular intestinal disorders (VID), including mesenteric ischemia, ischemic colitis, and intestinal angiodysplasia, have a global incidence of 8.11/100 000/year and a mortality of 1.26/100 000/year (15.5% death rate), rising from ~1% to ~3% in childhood to ~50% after 95 years. In the US, the incidence of acute vascular insufficiency of the intestine (AVII) is rising, warranting detailed trend analysis.
CDC WONDER death certificates (1999-2020) for adults > 25 years were analyzed using ICD-10 code N55. Age-adjusted mortality rates (AAMRs) per 100 000 were stratified by year, sex, race/ethnicity, and region. Joinpoint Regression (v5.2.0) calculated annual percent changes (APCs); significance was defined as < 0.05.
Overall AAMR declined from 9.35 (1999) to 5.81 (2020). Women had higher AAMRs (7.63; 95% CI: 7.6-7.66) than men (6.5; 95% CI: 6.49-6.56). By race/ethnicity, AAMRs were highest in NH American Indian (7.89; 95% CI: 7.57-8.21), NH Black (7.84; 95% CI: 7.75-7.9), NH White (7.25; 95% CI: 7.22-7.28), Hispanic (5.91; 95% CI: 5.83-6), and NH Asian (3.59; 95% CI: 3.5-3.68). Micropolitan areas had higher AAMRs (7.92) than metropolitan (6.99). Regional AAMRs were highest in the Midwest (7.7; 95% CI: 7.65-7.75), followed by South (7.17; 95% CI: 7.13-7.21), West (7.02; 95% CI: 6.96-7.07), and Northeast (6.85; 95% CI: 6.79-6.9). Kentucky had the highest state AAMR (9.67; 95% CI: 9.43-9.9), Hawaii the lowest (4.59; 95% CI: 4.31-4.87). Oklahoma, Rhode Island, Tennessee, West Virginia, and Wyoming ranked in the top 90th percentile.
Despite an overall decline, VID mortality remains high among women, NH American Indians, rural areas, and the Midwest-underscoring the need for targeted interventions.
血管性肠道疾病（VID），包括肠系膜缺血、缺血性结肠炎和肠道血管发育异常，全球发病率为每年8.11/10万，死亡率为每年1.26/10万（死亡率为15.5%），从儿童期的约1%上升至95岁后的约50%。在美国，肠道急性血管功能不全（AVII）的发病率正在上升，因此有必要进行详细的趋势分析。
使用国际疾病分类第十版（ICD - 10）编码N55对25岁以上成年人的疾病控制与预防中心（CDC）死因数据库（1999 - 2020年）进行分析。按年份、性别、种族/民族和地区对每10万人的年龄调整死亡率（AAMR）进行分层。连接点回归（v5.2.0）计算年度百分比变化（APC）；显著性定义为<0.05。
总体AAMR从1999年的9.35降至2020年的5.81。女性的AAMR（7.63；95%置信区间：7.6 - 7.66）高于男性（6.5；95%置信区间：6.49 - 6.56）。按种族/民族划分，美国印第安人（7.89；95%置信区间：7.57 - 8.21）、黑人（7.84；95%置信区间：7.75 - 7.9）、白人（7.25；95%置信区间：7.22 - 7.28）、西班牙裔（5.91；95%置信区间：5.83 - 6）和亚裔（3.59；95%置信区间：3.5 - 3.68）的AAMR最高。微型都市地区的AAMR（7.92）高于大都市地区（6.99）。地区AAMR在中西部最高（7.7；95%置信区间：7.65 - 7.75），其次是南部（7.17；95%置信区间：7.13 - 7.21）、西部（7.02；95%置信区间：6.96 - 7.07）和东北部（6.85；95%置信区间：6.79 - 6.9）。肯塔基州的州AAMR最高（9.67；95%置信区间：9.43 - 9.9），夏威夷最低（4.59；95%置信区间：4.31 - 4.87）。俄克拉荷马州、罗德岛州、田纳西州、西弗吉尼亚州和怀俄明州排名在前90百分位。
尽管总体呈下降趋势，但血管性肠道疾病在女性、美国印第安人、农村地区和中西部地区的死亡率仍然很高，这突出了进行有针对性干预的必要性。
