Danpanichkul Pojsakorn, Kanjanakot Yatawee, Kongarin Siwanart, Wattanachayakul Phuuwadith, Lopimpisuth Chawin, Saowapa Sakditad, Chaisrimaneepan Nattanicha, Dutta Priyata, Pang Yanfang, Duangsonk Kwanjit
Immunology Unit, Department of Microbiology, Faculty of Medicine, Chiang Mai University, Thailand (Pojsakorn Danpanichkul).
Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USA (Pojsakorn Danpanichkul, Sakditad Saowapa, Nattanicha Chaisrimaneepan).
Ann Gastroenterol. 2024 Jul-Aug;37(4):458-465. doi: 10.20524/aog.2024.0891. Epub 2024 Jun 14.
Vascular intestinal disorder (VID) is a condition with a low incidence, but a high mortality risk. The increasing prevalence of substance abuse and metabolic syndrome among young individuals could impact the burden of VID. This study aimed to evaluate the impact of VID on young individuals.
Our study harnessed data from the Global Burden of Disease study, spanning 2000 to 2019. With this extensive dataset, we conducted a comprehensive analysis of the prevalence, mortality rates, and impact on disability-adjusted life years (DALYs) related to VID among young individuals aged 15 to 49 years.
Globally, there were an estimated 32,628 cases, 3869 deaths, and 201,099 million DALYs attributed to VID in young individuals. Geographically, the regions of America had the highest burden of VID in young individuals. From 2000-2019, there was an increasing prevalence in all areas, with the most pronounced change observed in Southeast Asia (annual percentage change [APC] +2.17%, P<0.001). Over the study period, there was a more rapid increase in prevalence in males (APC +0.82%, P<0.001) than in females (APC +0.59%, P<0.001). Rates of death and DALYs declined in most regions, except for the Eastern Mediterranean region, where there was a slight increase (APC +0.85%, P<0.001 and 0.88%, P<0.001, respectively).
Over the past decade, the burden of VID in young individuals has been increasing, particularly in Southeast Asia and the Eastern Mediterranean region, necessitating immediate and inclusive measures to tackle the rising burden.
血管性肠病（VID）是一种发病率低但死亡风险高的疾病。年轻人中药物滥用和代谢综合征患病率的上升可能会影响VID的负担。本研究旨在评估VID对年轻人的影响。
我们的研究利用了全球疾病负担研究（2000年至2019年）的数据。借助这个庞大的数据集，我们对15至49岁年轻人中与VID相关的患病率、死亡率以及对伤残调整生命年（DALYs）的影响进行了全面分析。
全球范围内，估计有32,628例VID病例、3869例死亡以及201,099万伤残调整生命年归因于年轻人中的VID。在地理区域方面，美洲地区年轻人的VID负担最高。从2000年到2019年，所有地区的患病率都在上升，其中东南亚地区的变化最为显著（年百分比变化[APC]+2.17%，P<0.001）。在研究期间，男性患病率的上升速度（APC+0.82%，P<0.001）比女性（APC+0.59%，P<0.001）更快。除东地中海地区略有上升外（分别为APC+0.85%，P<0.001和0.88%，P<0.001），大多数地区的死亡率和伤残调整生命年率都有所下降。
在过去十年中，年轻人中VID的负担一直在增加，特别是在东南亚和东地中海地区，因此需要立即采取全面措施来应对不断上升的负担。
