Mantor Anthony, Bae Sonu, Burton Michael, Sheldon Jessica, Tzagournis Chase, Kaeding Christopher C, Magnussen Robert A, Flanigan David C, Barker Tyler
Jameson Crane Sports Medicine Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Boonshoft School of Medicine, Wright State University, Dayton, Ohio, USA.
Orthop J Sports Med. 2025 Sep 11;13(9):23259671251371291. doi: 10.1177/23259671251371291. eCollection 2025 Sep.
Metabolic syndrome (MetSy) is a global pandemic characterized by a cluster of interrelated abnormalities and risk factors. The prevalence of MetSy increases with advancing age. It is unknown whether increased age at the time of anterior cruciate ligament reconstruction (ACLR) is associated with an increased prevalence of MetSy.
To identify the association of age at ACLR with MetSy.
Cohort study; Level of evidence, 3.
Patients aged ≥18 years who underwent ACLR, with available blood pressure, blood lipids, hemoglobin A1c (HbA1c), and basic descriptive data, were included. All data were extracted from the medical records at a single academic institution. MetSy was defined as meeting any 3 of the following 5 criteria: (1) body mass index (BMI) ≥30 kg/m; (2) triglycerides ≥150 mg/dL; (3) high-density lipoprotein (HDL) <40 mg/dL in men and <50 mg/dL in women; (4) systolic blood pressure of ≥130 mmHg or diastolic blood pressure of ≥85 mmHg; or (5) fasting (estimated) glucose of ≥100 mg/dL. Patients were also separated into groups based on age at the time of ACLR: (1) 18-29, (2) 30-39, (3) 40-49, and (4) ≥50 years.
The final analysis consisted of 493 patients (age, 18-29 years [n = 139]; 30-39 years [n = 158]; 40-49 years [n = 135]; and ≥50 years [n = 61]). Based on the criteria, 190 (38.5%) patients who underwent ACLR displayed MetSy. The prevalence of MetSy was not significantly different between age groups ( = .70). The proportion of patients meeting the individual BMI ( = .41), triglyceride ( = .05), HDL ( = .41), and blood pressure ( = .82) criteria of MetSy was not significantly different between age groups. In contrast, approximately 59% (n = 82) of patients in the 18-29 years age group compared with 88.5% (n = 54) in the ≥50 years age group had an estimated fasting glucose of ≥100 mg/dL ( < .01). HbA1c% was also significantly increased in the ≥50 years age group compared with the younger age groups ( < .01).
Increased age at ACLR was not associated with MetSy but may be associated with an elevated HbA1c and estimated fasting glucose.
代谢综合征（MetSy）是一种全球性疾病，其特征为一系列相互关联的异常情况和风险因素。MetSy的患病率随年龄增长而增加。目前尚不清楚前交叉韧带重建（ACLR）时年龄增加是否与MetSy患病率增加相关。
确定ACLR时的年龄与MetSy之间的关联。
队列研究；证据等级，3级。
纳入年龄≥18岁且接受ACLR、有可用血压、血脂、糖化血红蛋白（HbA1c）和基本描述性数据的患者。所有数据均从单一学术机构的病历中提取。MetSy被定义为符合以下5项标准中的任意3项：（1）体重指数（BMI）≥30kg/m²；（2）甘油三酯≥150mg/dL；（3）男性高密度脂蛋白（HDL）<40mg/dL，女性<50mg/dL；（4）收缩压≥130mmHg或舒张压≥85mmHg；或（5）空腹（估算）血糖≥100mg/dL。患者还根据ACLR时的年龄分为以下几组：（1）18 - 29岁，（2）30 - 39岁，（3）40 - 49岁，（4）≥50岁。
最终分析包括493例患者（年龄，18 - 29岁[n = 139]；30 - 39岁[n = 158]；40 - 49岁[n = 135]；≥50岁[n = 61]）。根据标准，190例（38.5%）接受ACLR的患者表现出MetSy。各年龄组之间MetSy的患病率无显著差异（P = 0.70）。各年龄组之间符合MetSy个体BMI（P = 0.41）、甘油三酯（P = 0.05）、HDL（P = 0.41）和血压（P = 0.82）标准的患者比例无显著差异。相比之下，18 - 29岁年龄组约59%（n = 82）的患者与≥50岁年龄组88.5%（n = 54）的患者相比，估算空腹血糖≥100mg/dL（P < 0.01）。≥50岁年龄组的HbA1c%与较年轻年龄组相比也显著升高（P < 0.01）。
ACLR时年龄增加与MetSy无关，但可能与HbA1c升高和估算空腹血糖升高有关。
