Bae Sonu, Mantor Anthony, Price Hayden, Kaeding Christopher C, Magnussen Robert A, Flanigan David C, Barker Tyler
Sports Medicine Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43202, USA.
Department of Orthopaedic Surgery, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43202, USA.
Nutrients. 2025 Jul 24;17(15):2410. doi: 10.3390/nu17152410.
: Serum 25-hydroxyvitamin D (25(OH)D) concentrations are decreased with metabolic syndrome (MetSy), and low serum 25(OH)D concentrations are associated with poor outcomes following anterior cruciate ligament (ACL) reconstruction (ACLR). It is unknown whether serum 25(OH)D concentrations are decreased in patients with MetSy following ACLR. The purpose of this study was to investigate whether serum 25(OH)D concentrations are decreased with MetSy following ACLR. : This retrospective case-control study consisted of patients (≥18 years) who underwent ACLR. MetSy was defined as meeting any three of the five criteria (cases): (1) body mass index ≥ 30 kg/m, (2) triglycerides ≥ 150 mg/dL, (3) HDL < 40 mg/dL in men and <50 mg/dL in women, (4) systolic blood pressure ≥ 130 mmHg or diastolic blood pressure ≥ 85 mmHg, or (5) estimated (from hemoglobin A1c% [HbA1c]) fasting glucose ≥ 100 mg/dL. Participants without MetSy (meeting <3 criteria) served as controls. The first blood lipid, HbA1c, and 25(OH)D assessed ≥90 d after ACLR were included in this study. : The final analysis consisted of 219 patients (cases (with MetSy), n = 84; controls (without MetSy), n = 135). Serum 25(OH)D was significantly ( < 0.01) decreased (15.8%) in cases (mean [SD]; 25.1 [11.3] ng/mL) compared to controls (29.8 [14.8] ng/mL). An increasing number of MetSy components was associated with a decreased prevalence of vitamin D sufficiency ( < 0.01). : We conclude that serum 25(OH)D concentrations are significantly lower with MetSy. These preliminary findings could provide justification for assessing serum 25(OH)D following ACLR in patients with MetSy and assist with risk stratification.
血清25-羟维生素D（25(OH)D）浓度在代谢综合征（MetSy）患者中降低，且低血清25(OH)D浓度与前交叉韧带（ACL）重建（ACLR）术后不良预后相关。目前尚不清楚ACLR术后MetSy患者的血清25(OH)D浓度是否降低。本研究的目的是调查ACLR术后MetSy患者的血清25(OH)D浓度是否降低。：这项回顾性病例对照研究纳入了接受ACLR的患者（≥18岁）。MetSy被定义为符合五项标准中的任意三项（病例组）：（1）体重指数≥30kg/m²，（2）甘油三酯≥150mg/dL，（3）男性高密度脂蛋白（HDL）<40mg/dL，女性<50mg/dL，（4）收缩压≥130mmHg或舒张压≥85mmHg，或（5）（根据糖化血红蛋白A1c%[HbA1c]估算）空腹血糖≥100mg/dL。未患MetSy（符合<3项标准）的参与者作为对照组。本研究纳入了ACLR术后≥90天评估的首次血脂、HbA1c和25(OH)D数据。：最终分析纳入了219例患者（病例组（患有MetSy），n = 84；对照组（未患MetSy），n = 135）。与对照组（29.8[14.8]ng/mL）相比，病例组血清25(OH)D显著降低（<0.01）（降低15.8%）（平均值[标准差]；25.1[11.3]ng/mL）。MetSy组分数量增加与维生素D充足率降低相关（<0.01）。：我们得出结论，MetSy患者的血清25(OH)D浓度显著更低。这些初步研究结果可为评估MetSy患者ACLR术后的血清25(OH)D提供依据，并有助于进行风险分层。
