多基因风险评分（PRS）用于前列腺癌筛查：准备好进入黄金时段了吗？ - Suppr

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超能文献

Polygenic risk score (PRS) as prostate cancer screening: ready for primetime?

作者信息

Park Jinny, Aragon-Ching Jeanny B

机构信息

GU Medical Oncology, Inova Schar Cancer Institute, Fairfax, VA, USA.

出版信息

Ann Transl Med. 2025 Aug 31;13(4):39. doi: 10.21037/atm-25-84. Epub 2025 Aug 26.

DOI:10.21037/atm-25-84

PMID:40949682

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12432619/

Abstract

摘要

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本文引用的文献

Assessment of a Polygenic Risk Score in Screening for Prostate Cancer.多基因风险评分在前列腺癌筛查中的评估

N Engl J Med. 2025 Apr 10;392(14):1406-1417. doi: 10.1056/NEJMoa2407934.

Prostate Cancer: A Review.前列腺癌：综述

JAMA. 2025 Apr 22;333(16):1433-1446. doi: 10.1001/jama.2025.0228.

Cancer statistics, 2025.2025年癌症统计数据。

CA Cancer J Clin. 2025 Jan-Feb;75(1):10-45. doi: 10.3322/caac.21871. Epub 2025 Jan 16.

Results from 22 years of Followup in the Göteborg Randomized Population-Based Prostate Cancer Screening Trial.哥德堡基于人群的前列腺癌随机筛查试验22年随访结果。

J Urol. 2022 Aug;208(2):292-300. doi: 10.1097/JU.0000000000002696. Epub 2022 Apr 15.

The BARCODE1 Pilot: a feasibility study of using germline single nucleotide polymorphisms to target prostate cancer screening.BARCODE1 先导研究：利用胚系单核苷酸多态性进行前列腺癌筛查的可行性研究。

BJU Int. 2022 Mar;129(3):325-336. doi: 10.1111/bju.15535. Epub 2021 Aug 15.

Polygenic risk score for genetic evaluation of prostate cancer risk in Asian populations: A narrative review.多基因风险评分在亚洲人群前列腺癌风险遗传评估中的应用：一篇叙述性综述。

Investig Clin Urol. 2021 May;62(3):256-266. doi: 10.4111/icu.20210124.

Polygenic hazard score is associated with prostate cancer in multi-ethnic populations.多基因危险评分与多民族人群中的前列腺癌有关。

Nat Commun. 2021 Feb 23;12(1):1236. doi: 10.1038/s41467-021-21287-0.

Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations.全基因组多基因疾病风险评分可识别出与单基因突变风险相当的个体。

Nat Genet. 2018 Sep;50(9):1219-1224. doi: 10.1038/s41588-018-0183-z. Epub 2018 Aug 13.

Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.对超过 14 万名男性的关联分析确定了 63 个新的前列腺癌易感性位点。

Nat Genet. 2018 Jul;50(7):928-936. doi: 10.1038/s41588-018-0142-8. Epub 2018 Jun 11.

Screening for Prostate Cancer: US Preventive Services Task Force Recommendation Statement.前列腺癌筛查：美国预防服务工作组推荐声明。

JAMA. 2018 May 8;319(18):1901-1913. doi: 10.1001/jama.2018.3710.

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