多基因风险评分（PRS）用于前列腺癌筛查：准备好进入黄金时段了吗？ - Suppr

Suppr

超能文献

Polygenic risk score (PRS) as prostate cancer screening: ready for primetime?

作者信息

Park Jinny, Aragon-Ching Jeanny B

机构信息

GU Medical Oncology, Inova Schar Cancer Institute, Fairfax, VA, USA.

出版信息

Ann Transl Med. 2025 Aug 31;13(4):39. doi: 10.21037/atm-25-84. Epub 2025 Aug 26.

DOI:10.21037/atm-25-84

PMID:40949682

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12432619/

Abstract

摘要

相似文献

Polygenic risk score (PRS) as prostate cancer screening: ready for primetime?多基因风险评分（PRS）用于前列腺癌筛查：准备好进入黄金时段了吗？

Ann Transl Med. 2025 Aug 31;13(4):39. doi: 10.21037/atm-25-84. Epub 2025 Aug 26.

Polygenic Risk Score and Upgrading in Patients With Prostate Cancer Receiving Active Surveillance.多基因风险评分与接受主动监测的前列腺癌患者的病情进展

JAMA Oncol. 2025 Feb 1;11(2):168-171. doi: 10.1001/jamaoncol.2024.5398.

Addition of a Genetic Risk Score for Identification of Men with a Low Prostate-specific Antigen Level in Midlife at Risk of Developing Lethal Prostate Cancer.添加遗传风险评分以识别中年时前列腺特异性抗原水平低且有患致命性前列腺癌风险的男性。

Eur Urol Open Sci. 2023 Feb 18;50:27-30. doi: 10.1016/j.euros.2023.01.012. eCollection 2023 Apr.

Assessment of a Polygenic Risk Score in Screening for Prostate Cancer.多基因风险评分在前列腺癌筛查中的评估

N Engl J Med. 2025 Apr 10;392(14):1406-1417. doi: 10.1056/NEJMoa2407934.

Prostate cancer polygenic risk score and prediction of lethal prostate cancer.前列腺癌多基因风险评分与致命性前列腺癌的预测

NPJ Precis Oncol. 2022 Apr 8;6(1):25. doi: 10.1038/s41698-022-00266-8.

Preliminary effects of risk-adapted PSA screening for prostate cancer after integrating PRS-specific and age-specific variation.整合PRS特异性和年龄特异性变异后，风险适应性前列腺特异性抗原（PSA）筛查对前列腺癌的初步影响。

Front Genet. 2024 Aug 1;15:1387588. doi: 10.3389/fgene.2024.1387588. eCollection 2024.

Polygenic risk score and prostate specific antigen predict death from prostate cancer in men with intermediate aggressive cancer.

Int J Cancer. 2025 Sep 16. doi: 10.1002/ijc.70163.

Association of Prostate-Specific Antigen Levels with Prostate Cancer Risk in a Multiethnic Population: Stability Over Time and Comparison with Polygenic Risk Score.多民族人群中前列腺特异性抗原水平与前列腺癌风险的关联：随时间的稳定性及与多基因风险评分的比较。

Cancer Epidemiol Biomarkers Prev. 2022 Dec 5;31(12):2199-2207. doi: 10.1158/1055-9965.EPI-22-0443.

Variation in PSA Levels by Age, Adiposity, Race and Ethnicity, and Genetic Risk: Implications for Prostate Cancer Screening.前列腺特异性抗原（PSA）水平随年龄、肥胖、种族和遗传风险的变化：对前列腺癌筛查的影响。

Cancer Epidemiol Biomarkers Prev. 2025 Jun 3;34(6):972-981. doi: 10.1158/1055-9965.EPI-24-1710.

The Combined Effect of Polygenic Risk Score and Prostate Health Index in Chinese Men Undergoing Prostate Biopsy.多基因风险评分与前列腺健康指数对接受前列腺活检的中国男性的联合影响

J Clin Med. 2023 Feb 8;12(4):1343. doi: 10.3390/jcm12041343.

本文引用的文献

Assessment of a Polygenic Risk Score in Screening for Prostate Cancer.多基因风险评分在前列腺癌筛查中的评估

N Engl J Med. 2025 Apr 10;392(14):1406-1417. doi: 10.1056/NEJMoa2407934.

Prostate Cancer: A Review.前列腺癌：综述

JAMA. 2025 Apr 22;333(16):1433-1446. doi: 10.1001/jama.2025.0228.

Cancer statistics, 2025.2025年癌症统计数据。

CA Cancer J Clin. 2025 Jan-Feb;75(1):10-45. doi: 10.3322/caac.21871. Epub 2025 Jan 16.

Results from 22 years of Followup in the Göteborg Randomized Population-Based Prostate Cancer Screening Trial.哥德堡基于人群的前列腺癌随机筛查试验22年随访结果。

J Urol. 2022 Aug;208(2):292-300. doi: 10.1097/JU.0000000000002696. Epub 2022 Apr 15.

The BARCODE1 Pilot: a feasibility study of using germline single nucleotide polymorphisms to target prostate cancer screening.BARCODE1 先导研究：利用胚系单核苷酸多态性进行前列腺癌筛查的可行性研究。

BJU Int. 2022 Mar;129(3):325-336. doi: 10.1111/bju.15535. Epub 2021 Aug 15.

Polygenic risk score for genetic evaluation of prostate cancer risk in Asian populations: A narrative review.多基因风险评分在亚洲人群前列腺癌风险遗传评估中的应用：一篇叙述性综述。

Investig Clin Urol. 2021 May;62(3):256-266. doi: 10.4111/icu.20210124.

Polygenic hazard score is associated with prostate cancer in multi-ethnic populations.多基因危险评分与多民族人群中的前列腺癌有关。

Nat Commun. 2021 Feb 23;12(1):1236. doi: 10.1038/s41467-021-21287-0.

Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations.全基因组多基因疾病风险评分可识别出与单基因突变风险相当的个体。

Nat Genet. 2018 Sep;50(9):1219-1224. doi: 10.1038/s41588-018-0183-z. Epub 2018 Aug 13.

Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.对超过 14 万名男性的关联分析确定了 63 个新的前列腺癌易感性位点。

Nat Genet. 2018 Jul;50(7):928-936. doi: 10.1038/s41588-018-0142-8. Epub 2018 Jun 11.

Screening for Prostate Cancer: US Preventive Services Task Force Recommendation Statement.前列腺癌筛查：美国预防服务工作组推荐声明。

JAMA. 2018 May 8;319(18):1901-1913. doi: 10.1001/jama.2018.3710.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验