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静脉注射氯胺酮-美托咪定麻醉联合鞘内注射利多卡因用于红耳龟股前剖腹术:一项病例系列研究。

Intravenous ketamine-medetomidine anesthesia in combination with intrathecal lidocaine for prefemoral coeliotomy in red-eared sliders (): A case series study.

作者信息

Lutvikadić I, Šunje-Rizvan A, Kučlar Muftić S, Alić A, Šupić J, Maksimović A

机构信息

Department of Clinical Science, Veterinary Faculty, University of Sarajevo, Sarajevo, 71000, Bosnia and Herzegovina.

DVM Student, Department of Clinical Science, Veterinary Faculty, University of Sarajevo, Sarajevo, 71000, Bosnia and Herzegovina.

出版信息

Iran J Vet Res. 2025;26(1):83-87. doi: 10.22099/ijvr.2025.49481.7275.

DOI:10.22099/ijvr.2025.49481.7275
PMID:40949702
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12423995/
Abstract

BACKGROUND

Coeliotomy in chelonian species is performed to gain access to the abdominal cavity and requires general anesthesia. In reptile medicine, alfaxalone and propofol are often preferred, although the usage of these drugs is limited by cost and/or vascular access. Furthermore, according to a recent study, propofol produces significant oxidative stress in red-eared sliders (), and in such cases, a ketamine and medetomidine combination may provide a better choice.

CASE DESCRIPTION

Three owned red-eared sliders were separately presented with a history of recent lethargy, inappetence, dyspnea, and restlessness

FINDINGS/TREATMENT AND OUTCOME: In these three cases of chronic dystocia, a ketamine and medetomidine combination was used to achieve anesthesia induction for surgical treatment. Additionally, intrathecal administration of lidocaine was performed to achieve a potential analgesic effect in deeper intracoelomic reproductive organs. Preoperative changes in blood parameters were observed in one animal, suggesting abnormal kidney function. The same animal showed signs of resedation postoperatively, prolonged recovery, and had a fatal outcome 48 h after the surgery with signs of kidney damage in histopathological evaluation. In the recovery period, none of the surviving animals (n=2) showed neurological or respiratory complications that could be associated with subcarapacial sinus anesthesia administration or intrathecal local anesthesia.

CONCLUSION

According to our observations, intrathecal lidocaine administration provided sufficient analgesia during prefemoral coeliotomy and reproductive organ manipulation. These modes of anesthesia in chelonians require further investigation.

摘要

背景

对龟类动物进行剖腹手术是为了进入腹腔,需要全身麻醉。在爬行动物医学中,虽然阿法沙龙和丙泊酚常被优先选用,但这些药物的使用受到成本和/或血管通路的限制。此外,根据最近的一项研究,丙泊酚会在红耳龟中产生显著的氧化应激,在这种情况下,氯胺酮和美托咪定联合使用可能是更好的选择。

病例描述

三只家养红耳龟分别因近期嗜睡、食欲不振、呼吸困难和躁动不安前来就诊。

检查结果/治疗及结果:在这三例慢性难产病例中,使用氯胺酮和美托咪定联合诱导麻醉以进行手术治疗。此外,鞘内注射利多卡因,以期对更深层的腹腔内生殖器官产生潜在的镇痛效果。在一只动物身上观察到术前血液参数变化,提示肾功能异常。同一只动物术后出现再次镇静、恢复时间延长的迹象,并在术后48小时死亡,组织病理学评估显示有肾损伤迹象。在恢复期,存活的动物(n = 2)均未出现与缘下窦麻醉给药或鞘内局部麻醉相关的神经或呼吸并发症。

结论

根据我们的观察,鞘内注射利多卡因在股前剖腹术和生殖器官操作期间提供了足够的镇痛效果。龟类动物的这些麻醉方式需要进一步研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29f5/12423995/6eb4a99bab68/ijvr-26-83-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29f5/12423995/4c608d84fea2/ijvr-26-83-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29f5/12423995/42f9f5f8fc38/ijvr-26-83-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29f5/12423995/6bfa0b7a568d/ijvr-26-83-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29f5/12423995/7e54d3c391ef/ijvr-26-83-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29f5/12423995/6eb4a99bab68/ijvr-26-83-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29f5/12423995/4c608d84fea2/ijvr-26-83-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29f5/12423995/42f9f5f8fc38/ijvr-26-83-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29f5/12423995/6bfa0b7a568d/ijvr-26-83-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29f5/12423995/7e54d3c391ef/ijvr-26-83-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29f5/12423995/6eb4a99bab68/ijvr-26-83-g005.jpg

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