Rousseau-Merck M F, Nogues C, Roth A, Nezelof C, Bourdeau A, Leblanc A, Trincard M D
Pediatr Pathol. 1985;3(2-4):155-64. doi: 10.3109/15513818509078781.
Hypercalcemic infantile renal tumors without bone metastases should be considered to be a heterogeneous tumoral entity. Histological and ultrastructural features, different from those of nephroblastoma, should not be exclusively linked with malignant rhabdoid tumors of the kidney. This is reported by the present case, which appears to be a cellular variant of mesoblastic nephroma and was successfully serially transplanted to nude mice. The causes of hypercalcemia in infantile renal tumors are probably related either to NH2-terminal parathormone or to prostaglandin E2 production by the tumoral cells.
无骨转移的高钙血症婴儿肾肿瘤应被视为一种异质性肿瘤实体。其组织学和超微结构特征与肾母细胞瘤不同，不应仅与肾恶性横纹肌样瘤相关。本病例报告了这一情况，该病例似乎是中胚层肾瘤的一种细胞变体，并成功地连续移植到裸鼠体内。婴儿肾肿瘤中高钙血症的原因可能与肿瘤细胞产生的氨基末端甲状旁腺激素或前列腺素E2有关。
