Zhao Binyu, Yang Xiaobin, Jiang Jinquan, Xu Qiqi, Li Bo
Department of Intervention, The Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine No. 831 Longtaiguan Road, Fengxi New City, Xixian New District, Xianyang 712000, Shaanxi, China.
Interventional Surgery Center, Xijing Hospital, The Fourth Military Medical University No. 127 Changle West Road, Xi'an 710032, Shaanxi, China.
Am J Transl Res. 2025 Aug 15;17(8):6166-6179. doi: 10.62347/CDFB3086. eCollection 2025.
To evaluate the efficacy of AngioJet mechanical thrombectomy combined with drug-coated balloon (DCB) therapy in patients with lower extremity arterial occlusive disease (ASO) and diabetic foot ulcers (DFU), focusing on its effects on hemodynamics, glycemic control, inflammatory markers, and one-year ulcer recurrence.
This retrospective study involved 198 patients with ASO and DFU treated between April 2021 and March 2024. Of these, 104 received combined AngioJet and DCB therapy (combined group), while 94 underwent mechanical thrombectomy alone (control group). Clinical outcomes, hemodynamic parameters, blood glucose levels, inflammatory markers, and functional scores were assessed before and after treatment. Ulcer recurrence was evaluated during a one-year follow-up period.
The combined group exhibited significantly better clinical outcomes and greater improvements in hemodynamics (pulse index and resistive index), glycemic control (fasting/postprandial glucose and HbA1c), and inflammatory markers (CRP, TNF-α, IL-6) compared to the control group. Functional indicators, including the ankle-brachial index, Rutherford and Wagner grades, and claudication distance, improved more in the combined group. The one-year recurrence rate was significantly lower in the combined group.
The combined AngioJet-DCB approach demonstrates enhanced clinical efficacy in the management of ASO-DFU by improving hemodynamic outcomes and reducing the risk of ulcer recurrence.
评估AngioJet机械血栓切除术联合药物涂层球囊（DCB）治疗下肢动脉闭塞性疾病（ASO）合并糖尿病足溃疡（DFU）患者的疗效，重点关注其对血流动力学、血糖控制、炎症标志物及溃疡一年复发率的影响。
这项回顾性研究纳入了2021年4月至2024年3月期间接受治疗的198例ASO合并DFU患者。其中，104例接受了AngioJet与DCB联合治疗（联合组），而94例仅接受了机械血栓切除术（对照组）。在治疗前后评估临床结局、血流动力学参数、血糖水平、炎症标志物及功能评分。在一年的随访期内评估溃疡复发情况。
与对照组相比，联合组在临床结局方面表现显著更好，在血流动力学（脉搏指数和阻力指数）、血糖控制（空腹/餐后血糖及糖化血红蛋白）及炎症标志物（CRP、TNF-α、IL-6）方面改善更大。包括踝肱指数、卢瑟福和瓦格纳分级及跛行距离在内的功能指标在联合组改善更为明显。联合组的一年复发率显著更低。
AngioJet-DCB联合治疗方法通过改善血流动力学结局及降低溃疡复发风险，在ASO-DFU的治疗中显示出更高的临床疗效。
