Wei Ze-Kun, Li Cun-Yang, Liu Zhi-Yun, Wang Bo-Lin, Wang Can, Liu Yang, Ba Te-Jin, Kong Li, Zhang Fei-Hu
The First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, China.
Department of Emergency Center, Shandong University of Traditional Chinese Medicine Affiliated Hospital, Jinan, China.
Front Psychiatry. 2025 Aug 28;16:1622973. doi: 10.3389/fpsyt.2025.1622973. eCollection 2025.
Motoric Cognitive Risk Syndrome (MCR), defined by cognitive complaints and slow gait, is a pre-dementia condition linked to metabolic dysfunction. The triglyceride-glucose (TyG) index and its composite derivatives are surrogate markers of insulin resistance and may contribute to cognitive decline. This study investigated the associations between TyG-related indices and MCR risk in middle-aged and older adults with depressive symptoms, focusing on nonlinear relationships and subgroup modifications.
This study included 5,657 participants aged ≥45 years from the China Health and Retirement Longitudinal Study (CHARLS). Associations between four TyG-related indices (TyG, TyG-BMI, TyG-WC, TyG-WHtR) and MCR were assessed using logistic regression. Nonlinear associations were examined via generalized additive models and two-piecewise linear regression. Stratified analyses explored effect modifications by age, sex, education, and depressive status.
All TyG-related indices were positively associated with MCR. TyG-BMI demonstrated the strongest and most consistent association, with a significant threshold at 276.05. Below this point, MCR risk increased with TyG-BMI (OR = 1.01; 95% CI: 1.004-1.017; P = 0.003), while no association was found above it (P = 0.416). Similar nonlinear trends were observed in depressive individuals. Subgroup analyses indicated stronger associations in older adults (≥60 years).
TyG-BMI demonstrates a nonlinear association with MCR risk and may serve as an accessible biomarker for early cognitive risk detection in depressive individuals.
运动认知风险综合征（MCR）由认知主诉和步态缓慢定义，是一种与代谢功能障碍相关的痴呆前期病症。甘油三酯-葡萄糖（TyG）指数及其复合衍生物是胰岛素抵抗的替代标志物，可能导致认知能力下降。本研究调查了抑郁症状的中老年人群中TyG相关指标与MCR风险之间的关联，重点关注非线性关系和亚组差异。
本研究纳入了来自中国健康与养老追踪调查（CHARLS）的5657名年龄≥45岁的参与者。使用逻辑回归评估四个TyG相关指标（TyG、TyG-BMI、TyG-WC、TyG-WHtR）与MCR之间的关联。通过广义相加模型和两段式线性回归检验非线性关联。分层分析探讨了年龄、性别、教育程度和抑郁状态的效应修正。
所有TyG相关指标均与MCR呈正相关。TyG-BMI表现出最强且最一致的关联，阈值为276.05。低于此点，MCR风险随TyG-BMI增加（OR = 1.01；95% CI：1.004 - 1.017；P = 0.003），而高于此点则未发现关联（P = 0.416）。在抑郁个体中观察到类似的非线性趋势。亚组分析表明，在老年人（≥60岁）中关联更强。
TyG-BMI与MCR风险呈非线性关联，可作为抑郁个体早期认知风险检测的便捷生物标志物。
