Sun Hongli, He Wei, Bu Jingyu, Zhang Huifang, Huang Huimei, Ma Kai
Shaanxi Institute for Pediatric Diseases, Xi'an Key Laboratory of Children's Health and Diseases, Xi'an Children's Hospital (Affiliated Children's Hospital of Xi'an Jiaotong University), Xi'an, Shaanxi, China.
Department of Laboratory, Xi'an Children's Hospital (Affiliated Children's Hospital of Xi'an Jiaotong University), Xi'an, Shaanxi, China.
Front Psychiatry. 2025 Mar 10;16:1533819. doi: 10.3389/fpsyt.2025.1533819. eCollection 2025.
The relationship between the triglyceride-glucose (TyG) index, its combination with obesity indicators, and depression remains understudied in the American population.
This cross-sectional study analyzed data from 10,423 adults in the National Health and Nutrition Examination Survey (NHANES) conducted between 2005 and 2020. We employed multivariable logistic regression analysis, smoothing techniques, generalized additive models, stratified analyses, and sensitivity analyses to examine the relationship between TyG, its combination (TyG-WC, TyG-WHtR, TyG-BMI) with obesity indicators, and depression.
The results indicate that the TyG index, TyG-WC, TyG-WHtR, TyG-BMI, and depression exhibited a significant statistical association with depressive symptoms (all P for trend < 0.001). Specifically, a one-unit increase in the TyG index correlated with a 37% increase in the risk of depressive symptoms (95% CI: 1.21-1.55), a one-unit increase in TyG-WC correlated with a 3.26 times increase in the risk of depressive symptoms (95% CI: 2.22-4.80), a one-unit increase in TyG-WHtR correlated with a 27% increase in the risk of depressive symptoms (95% CI: 1.18-1.36), and a one-unit increase in TyG-BMI correlated with a 2.30 times increase in the risk of depressive symptoms (95% CI: 1.72-3.08). There was a significant nonlinear correlation between TyG-WC, TyG-WHtR, and TyG-BMI with depressive symptoms (all P for nonlinearity < 0.001), except for a linear correlation between the TyG index and depressive symptoms (P for linearity < 0.001).
Monitoring the TyG index, TyG-WC, TyG-WHtR, TyG-BMI may facilitate depression risk assessment and prevention.
甘油三酯-葡萄糖（TyG）指数及其与肥胖指标的组合和抑郁症之间的关系在美国人群中仍未得到充分研究。
这项横断面研究分析了2005年至2020年期间进行的美国国家健康与营养检查调查（NHANES）中10423名成年人的数据。我们采用多变量逻辑回归分析、平滑技术、广义相加模型、分层分析和敏感性分析来研究TyG、其与肥胖指标的组合（TyG-WC、TyG-WHtR、TyG-BMI）和抑郁症之间的关系。
结果表明，TyG指数、TyG-WC、TyG-WHtR、TyG-BMI和抑郁症与抑郁症状存在显著的统计学关联（所有趋势P值<0.001）。具体而言，TyG指数每增加一个单位，抑郁症状风险增加37%（95%CI：1.21-1.55）；TyG-WC每增加一个单位，抑郁症状风险增加3.26倍（95%CI：2.22-4.80）；TyG-WHtR每增加一个单位，抑郁症状风险增加27%（95%CI：1.18-1.36）；TyG-BMI每增加一个单位，抑郁症状风险增加2.30倍（95%CI：1.72-3.08）。TyG-WC、TyG-WHtR和TyG-BMI与抑郁症状之间存在显著的非线性相关性（所有非线性P值<0.001），TyG指数与抑郁症状之间存在线性相关性（线性P值<0.001）。
监测TyG指数、TyG-WC、TyG-WHtR、TyG-BMI可能有助于抑郁症风险评估和预防。
