Hua Fan, Chang Liu, Chun Li Xin
Department of Psychiatry, The Second People's Hospital of Hunan Province (Brain Hospital of Hunan Province), Changsha, Hunan, China.
Front Psychiatry. 2025 Aug 28;16:1585083. doi: 10.3389/fpsyt.2025.1585083. eCollection 2025.
There are increasing numbers of patients suffering from gastrointestinal disorders who are at primary risk for depression. These patients often have no awareness of their depression and therefore choose to see their gastroenterologists. Normally gastroenterologists advise the patients to undergo gastroscopy to investigate their possible digestive disorders while overlooking their depression. This study investigated the prevalence of the comorbidities between depression, depression-anxiety and organic diseases of upper gastrointestinal tract (UGI) among patients receiving gastroscopy in a large general hospital in China.
A total of 707 patients who agreed to recommendation for gastroscopy were investigated using the nine-item Patient Health Questionnaire (PHQ-9). The patients of PHQ-9 scores ≥10 were further interviewed using the Hamilton depressive scale (HAMD), Hamilton anxiety scale (HAMA) and DSM-IV to confirm the diagnosis.
Altogether, 412 patients were found to suffer from organic diseases of UGI based on the gastroscopy results. Of these, 51 patients and 34 were diagnosed with major depression and depression-anxiety respectively. The detection rate of depression by gastroenterologists was 3.92% while no depression-anxiety was diagnosed. Multiple logistic regression showed the course of disease, number of gastroscopies and age were significantly associated with major depression while educational level, income, age, and number of gastroscopies were significantly associated with depression-anxiety.
The comorbidities rates between depression, depression-anxiety and organic diseases of UGI are higher than the general population in China. However, the detection rates of the comorbidities by gastroenterologists are low.
患有胃肠道疾病且面临抑郁症主要风险的患者数量日益增加。这些患者往往未意识到自己患有抑郁症，因此会选择去看胃肠病医生。通常，胃肠病医生会建议患者进行胃镜检查以排查可能的消化系统疾病，却忽略了他们的抑郁症。本研究调查了在中国一家大型综合医院接受胃镜检查的患者中，抑郁症、抑郁焦虑共病与上消化道（UGI）器质性疾病之间的共病率。
使用九项患者健康问卷（PHQ - 9）对总共707名同意接受胃镜检查建议的患者进行调查。PHQ - 9得分≥10的患者进一步使用汉密尔顿抑郁量表（HAMD）、汉密尔顿焦虑量表（HAMA）和《精神疾病诊断与统计手册第四版》（DSM - IV）进行访谈以确诊。
根据胃镜检查结果，共发现412名患者患有UGI器质性疾病。其中，分别有51名和34名患者被诊断为重度抑郁症和抑郁焦虑共病。胃肠病医生对抑郁症的检出率为3.92%，而未诊断出抑郁焦虑共病。多因素逻辑回归显示，病程、胃镜检查次数和年龄与重度抑郁症显著相关，而教育程度、收入、年龄和胃镜检查次数与抑郁焦虑共病显著相关。
在中国，抑郁症、抑郁焦虑共病与UGI器质性疾病之间的共病率高于普通人群。然而，胃肠病医生对这些共病的检出率较低。
