Survival outcomes of thoracic radiotherapy in addition to first-line immunotherapy in metastatic non-small cell lung cancer: a multicenter, propensity score-matched analysis.

BACKGROUND

Immune checkpoint inhibitors (ICIs) as part of first-line treatment are becoming increasingly significant in metastatic non-small cell lung cancer (NSCLC). We aimed to investigate the efficacy and safety of thoracic radiotherapy (TRT) in addition to first-line ICIs in metastatic NSCLC.

METHODS

From January 2017 to August 2023, we retrospectively collected the information of 82 patients with metastatic NSCLC who were treated with first-line ICIs and radiotherapy (RT). Patients were divided into the TRT group (n=35) and the non-TRT group (n=47). The efficacy and safety were analyzed. Propensity score matching (PSM) was applied. Inverse probability of treatment weighting (IPTW) was used as a sensitivity analysis.

RESULTS

The median follow-up was 31.4 months (range, 4.0-81.4 months). Before PSM, the median overall survival (OS; 38.1 . 17.9 months, P=0.01) and median progression-free survival (PFS; 14.9 . 8.3 months, P=0.001) were significantly improved in the TRT group. After PSM, there were 18 patients in each group. Both the median OS [not reached (NR) . 26.8 months, P=0.02] and median PFS (16.3 . 7.5 months, P<0.001) still favored in the TRT group. The IPTW method yielded similar results [OS: hazard ratio (HR) =0.335, P=0.01; PFS: HR =0.442, P=0.02]. The most common grade 3 or worse toxicity was bone marrow suppression (18/82, 22.0%). No significant difference was found in grade 3 or worse treatment-related pneumonia between the two groups either before (5.7% . 6.4%, P>0.99) or after matching (0 . 5.6%, P>0.99).

CONCLUSIONS

The addition of TRT to first-line immunotherapy (IO) may be associated with improved survival in metastatic NSCLC. However, given the retrospective nature and limited sample size, these findings are exploratory and warrant validation in larger randomized trials.