Agrawal Ashwin, Teitelbaum Jonathan E, Shertz-Dipietro Wendy, Vavrukh Petro
Department of Pediatric Gastroenterology, RWJBarnabas Health, Long Branch, USA.
Department of Pathology, Monmouth Medical Center, Long Branch, USA.
Cureus. 2025 Aug 12;17(8):e89867. doi: 10.7759/cureus.89867. eCollection 2025 Aug.
Eosinophilic esophagitis results in a chronic immune-mediated condition of the esophagus characterized by esophageal dysfunction and eosinophil-predominant inflammation. While food-based oral immunity therapy (OIT) is a recognized trigger for eosinophilic esophagitis, the impact of sublingual immunotherapy (SLIT) for aeroallergens is less well established. We present an unusual case of eosinophilic esophagitis in a 14-year-old male induced by SLIT and resolved after discontinuing SLIT with Timothy grass pollen allergy extract (GRASTEK®, ALK-Abelló, Inc., Bedminster, USA), which, to our knowledge, has not been previously reported.
嗜酸性粒细胞性食管炎会导致一种慢性免疫介导的食管疾病，其特征为食管功能障碍和以嗜酸性粒细胞为主的炎症。虽然基于食物的口服免疫疗法（OIT）是嗜酸性粒细胞性食管炎公认的诱发因素，但舌下免疫疗法（SLIT）对吸入性变应原的影响尚不明确。我们报告了一例不寻常的病例，一名14岁男性因SLIT诱发嗜酸性粒细胞性食管炎，停用美国新泽西州贝丁顿ALK-阿伯洛公司生产的梯牧草花粉变应原提取物（GRASTEK®）进行的SLIT后病情缓解，据我们所知，此前尚无此类病例报道。
