氯化铝对大鼠升结肠的影响。

Effect of aluminum chloride on ascending colon of the rat.

作者信息

Alvarez F J, Carvajal A, Velasco A

出版信息

Pharmacol Res Commun. 1985 Dec;17(12):1121-7. doi: 10.1016/0031-6989(85)90024-4.

Abstract

Aluminum chloride (2.48 X 10(-4) to 1.24 X 10(-3) M) inhibits spontaneous motility of ascending colon of the rat. Resting tension was not affected. At concentrations between 2.07 X 10(-5) to 1.24 X 10(-3) M it inhibited in a dose-dependent manner the contractions induced by maximal doses of acetylcholine. Higher doses produced a very marked inhibition that was attributable to acidification of the medium. The inhibiting effect was more intense when the incubation medium contained an excess of calcium (3.6 and 4.3 mM) or theobromine (10(-4) and 10(-3) M). This inhibiting effect tended to be smaller in the presence of low calcium (0.6 and 1.0 mM) or verapamil (3 X 10(-8) and 10(-7) M).

摘要

氯化铝（2.48×10⁻⁴至1.24×10⁻³M）可抑制大鼠升结肠的自发运动。静息张力不受影响。在2.07×10⁻⁵至1.24×10⁻³M的浓度范围内，它以剂量依赖性方式抑制最大剂量乙酰胆碱诱导的收缩。更高剂量会产生非常明显的抑制作用，这归因于培养基的酸化。当孵育培养基中含有过量的钙（3.6和4.3mM）或可可碱（10⁻⁴和10⁻³M）时，抑制作用更强。在低钙（0.6和1.0mM）或维拉帕米（3×10⁻⁸和10⁻⁷M）存在的情况下，这种抑制作用往往较小。