Feng Keng, Zhu Lingling, Luo Yudi, Ruan Luhai, Li Derong, Li Xiang, Li Ling, Wu Ling
Center of Reproductive Medicine, Yulin Maternal and Child Health Hospital, Yulin, China.
Front Endocrinol (Lausanne). 2025 Aug 28;16:1609556. doi: 10.3389/fendo.2025.1609556. eCollection 2025.
To compare single versus double autologous platelet-rich plasma (PRP) intrauterine infusion effects on endometrial receptivity and pregnancy outcomes in patients with thin endometrium.
This randomized controlled trial included 100 patients with thin endometrium and infertility, assigned to single (n=50) or double (n=50) infusion groups. The single group received 1.0 ml of PRP on day 11 of the hormone replacement therapy-frozen embryo transfer (HRT-FET) cycle, while the double group received 1.0 ml on both days 11 and 13. Primary outcomes included endometrial thickness, receptivity changes, and clinical pregnancy rates; secondary outcomes were cycle cancellation rate, miscarriage rate, and endometrial hemodynamics. Statistical analysis was conducted using SPSS 26.0.
The double PRP infusion group exhibited measurable improvements in endometrial and early pregnancy outcomes. 1) Endometrial thickness increased (8.42 ± 0.53 mm vs 7.96 ± 0.45 mm, P<0.01); 2) Hemodynamic parameters improved for resistance index (RI) (1.72 ± 0.08 vs 1.79 ± 0.08, P<0.01) and pulsatility index (PI) (3.83 ± 0.64 vs 4.38 ± 0.68, P<0.01); 3) Clinical outcomes: lower cycle cancellation rate (10.0% vs 26.0%, P=0.037) and higher clinical pregnancy rate (48.9% vs 27.0%, P=0.043).However, early miscarriage rates were similar between groups (p > 0.99).
Compared to a single intrauterine infusion, double intrauterine PRP infusion may enhance the receptivity of a thin endometrium and improve clinical pregnancy outcomes. However, since the study population did not include patients with thin endometrium who also have a history of recurrent implantation failure or recurrent miscarriage, caution is advised when applying these findings to this specific group. Furthermore, these conclusions require validation through larger, randomized, multicenter trials.
比较单次与双次自体富血小板血浆（PRP）宫腔内输注对薄型子宫内膜患者子宫内膜容受性和妊娠结局的影响。
本随机对照试验纳入100例薄型子宫内膜且不孕的患者，分为单次输注组（n = 50）和双次输注组（n = 50）。单次输注组在激素替代疗法-冻融胚胎移植（HRT-FET）周期的第11天接受1.0 ml PRP，而双次输注组在第11天和第13天均接受1.0 ml PRP。主要结局包括子宫内膜厚度、容受性变化和临床妊娠率；次要结局为周期取消率、流产率和子宫内膜血流动力学。使用SPSS 26.0进行统计分析。
双次PRP输注组在子宫内膜和早期妊娠结局方面有显著改善。1）子宫内膜厚度增加（8.42±0.53 mm对7.96±0.45 mm，P<0.01）；2）血流动力学参数改善，阻力指数（RI）（1.72±0.08对1.79±0.08，P<0.01）和搏动指数（PI）（3.83±0.64对4.38±0.68，P<0.01）；3）临床结局：周期取消率较低（10.0%对26.0%，P = 0.037），临床妊娠率较高（48.9%对27.0%，P = 0.043）。然而，两组之间的早期流产率相似（P>0.99）。
与单次宫腔内输注相比，双次宫腔内PRP输注可能增强薄型子宫内膜的容受性并改善临床妊娠结局。然而，由于研究人群未包括有反复种植失败或反复流产病史的薄型子宫内膜患者，将这些结果应用于该特定人群时建议谨慎。此外，这些结论需要通过更大规模的随机多中心试验进行验证。
