Avicenna Fertility Clinic, Avicenna Research Institute, ACECR, Tehran, Iran.
Gynecology and reproductive biology Department, Kowsar polyclinic, Imam Khomeini square, Pardis Town, Tehran Province, Iran.
JBRA Assist Reprod. 2022 Jan 17;26(1):84-87. doi: 10.5935/1518-0557.20210046.
Repeated implantation failure (RIF) is a major challenge in reproductive medicine. On the other hand, there has not yet been established a confirmed outcome regarding the usage of platelet-rich plasma (PRP) in women undergoing intracytoplasmic injection (ICSI) or in-vitro fertilization (IVF); hence, the objective of this study was to evaluate the effect of the intrauterine infusion of PRP on pregnancy outcomes in women undergoing ICSI.
In this prospective double-blind clinical trial, 100 women with at least two previous unexplained RIF, who were candidates for frozen-thawed embryo transfer, were allocated into two groups. One subgroup of patients was treated by intrauterine infusion of PRP (0.5CC, contained platelet 4-5 times more than a peripheral blood sample, which was performed 48 hours before blastocyst transfer) and the other subgroup was treated by intrauterine catheterization only. We compared the implantation rates between the two groups.
The pregnancy rate was 20% in the intervention subgroup, while in the control subgroup it was 13.33%; therefore, there was a significant statistical difference between the two groups.
According to this paper, PRP could be successful in improving the pregnancy outcome in RIF patients, and we highly recommend other studies with larger samples to confirm the PRP therapy efficacy in RIF patients.
反复着床失败（RIF）是生殖医学中的一个主要挑战。另一方面，关于在接受胞浆内单精子注射（ICSI）或体外受精（IVF）的女性中使用富含血小板的血浆（PRP）的效果尚未确定明确的结果；因此，本研究的目的是评估 PRP 宫内输注对接受 ICSI 的女性妊娠结局的影响。
在这项前瞻性双盲临床试验中，100 名至少有两次不明原因 RIF 的女性，作为冷冻解冻胚胎移植的候选者，被分为两组。一组患者接受 PRP（0.5CC，包含比外周血样本多 4-5 倍的血小板）宫内输注治疗，另一组仅接受宫内导管插入术治疗。我们比较了两组的着床率。
干预亚组的妊娠率为 20%，而对照组为 13.33%；因此，两组之间存在显著的统计学差异。
根据本文，PRP 可以成功改善 RIF 患者的妊娠结局，我们强烈建议进行其他样本量更大的研究，以确认 PRP 治疗 RIF 患者的疗效。
