Sukesi Lilik, Sribudiani Yunia, Usman Steven Yulius, Yonatan Eric Ricardo, Widiasta Ahmedz, Indraswari Noormarina, Bandiara Ria, Soetedjo Nanny N M
Division of Nephrology and Hypertension, Department of Internal Medicine, Faculty of Medicine Universitas Padjadjaran/Hasan Sadikin General Hospital Bandung Indonesia.
Department Biomedical Sciences, Division of Biochemistry and Molecular Biology, Faculty of Medicine Universitas Padjadjaran/Hasan Sadikin General Hospital Bandung Indonesia.
Chronic Dis Transl Med. 2025 May 13;11(3):197-204. doi: 10.1002/cdt3.70008. eCollection 2025 Sep.
Elevated high blood pressure is controlled by complicated, little-understood genetic and epigenetic pathways that are influenced by both heritable and environmental variables. Many adult systolic and diastolic blood pressure-related genomic loci have been identified through previous genome-wide association studies (GWAS); meanwhile, studies specifically on Asian adult populations have not been done. This study aims to comprehensively assess and summarize any gene changes that have been studied and see whether there is a possible influence between epigenetic changes and hypertension in Asian adults.
This evidence-based analysis is based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 statement and has been registered in PROSPERO under registration number [CRD42024622261]. The data were processed qualitatively to assess the risk of bias using the Newcastle-Ottawa Scale (NOS) and Agency for Health Research and Quality (AHRQ) standards as the threshold. Our study in particular shows that epigenetic modifications may play a role in hypertension, particularly in Asian individuals.
A total of 28 studies were selected for qualitative evaluation. In the adult Asian population, 26 publications (92.8%) reported a relationship between blood pressure and epigenetics. Every study describes a distinct gene or location associated with hypo- or hypermethylation. Elevated systolic and diastolic blood pressure was linked to variations of several single-nucleotide polymorphisms (SNPs), cytosine phosphate guanines (CPGs), and other monogenic genes.
Alterations in epigenetic modifications in potential genes or loci are linked to systolic and diastolic blood pressure of Asian adult populations. CRD42024622261.
高血压升高受复杂且鲜为人知的遗传和表观遗传途径控制，这些途径受遗传和环境变量影响。通过先前的全基因组关联研究（GWAS）已鉴定出许多与成人收缩压和舒张压相关的基因组位点；与此同时，尚未针对亚洲成年人群体进行专门研究。本研究旨在全面评估和总结已研究的任何基因变化，并查看表观遗传变化与亚洲成年人高血压之间是否存在可能的影响。
本循证分析基于系统评价和荟萃分析的首选报告项目（PRISMA）2020声明，并已在PROSPERO注册，注册号为[CRD42024622261]。使用纽卡斯尔 - 渥太华量表（NOS）和卫生研究与质量机构（AHRQ）标准作为阈值对数据进行定性处理，以评估偏倚风险。我们的研究特别表明，表观遗传修饰可能在高血压中起作用，尤其是在亚洲个体中。
共选择28项研究进行定性评估。在成年亚洲人群中，26篇出版物（92.8%）报告了血压与表观遗传学之间的关系。每项研究都描述了一个与低甲基化或高甲基化相关的独特基因或位置。收缩压和舒张压升高与几种单核苷酸多态性（SNP）、胞嘧啶 - 磷酸 - 鸟嘌呤（CPG）和其他单基因的变异有关。
潜在基因或位点的表观遗传修饰改变与亚洲成年人群体的收缩压和舒张压有关。CRD42024622261。
