Ungerer A, Back M, Schmitt P
Physiol Behav. 1985 Dec;35(6):855-60. doi: 10.1016/0031-9384(85)90250-1.
The effects of acetoxycycloheximide (AXM) (7 mg/kg) and anisomycin (ANI) (25 and 150 mg/kg) on approach and escape responses induced by hypothalamic stimulation were studied in a situation in which male Swiss mice could initiate a continuous brain stimulation train by pressing a lever at one end of a box (ON-lever) and terminate this stimulation train by pressing a lever at the other end of the box (OFF-lever). AXM and ANI induced a large decrease in ON-OFF responses regardless of the level of stimulation presented (a low level just above the stimulation threshold and a high level which was twice the low level). Correspondingly, a significant increase was observed in the mean time during which animals remained unstimulated (NST) whereas mean time during which animals remained stimulated (ST) increased only slightly. The relative NST increase after treatment was always greater than the relative ST increase either at sites where before treatment NST was greater than ST or at sites where NST was shorter than ST. However, the animals in this latter electrode placement group (ST greater than NST) continued to shuttle and to make lever-pressing responses on the ON-lever, whereas the animals in the other placement group (ST less than NST) did not. These results are discussed in terms of possible interactions between disruptions of reinforcing systems induced by protein inhibitors and their effects on memory.
研究了乙酰氧基环己酰亚胺（AXM，7毫克/千克）和茴香霉素（ANI，25毫克/千克和150毫克/千克）对下丘脑刺激诱发的趋近和逃避反应的影响。实验情境中，雄性瑞士小鼠可通过按压盒子一端的杠杆（开启杠杆）启动连续的脑刺激训练，并通过按压盒子另一端的杠杆（关闭杠杆）终止该刺激训练。无论呈现的刺激水平如何（略高于刺激阈值的低水平和为低水平两倍的高水平），AXM和ANI均导致开启 - 关闭反应大幅减少。相应地，观察到动物未受刺激的平均时间（NST）显著增加，而动物受刺激的平均时间（ST）仅略有增加。治疗后NST的相对增加总是大于ST的相对增加，无论是在治疗前NST大于ST的部位，还是在NST短于ST的部位。然而，后一组电极放置（ST大于NST）的动物继续穿梭并在开启杠杆上做出按压杠杆反应，而另一组放置（ST小于NST）的动物则没有。根据蛋白质抑制剂引起的强化系统破坏及其对记忆的影响之间可能的相互作用对这些结果进行了讨论。
