Zou Xiangni, Tang Yuyang, Shi Pei
Heilongjiang University of Chinese Medicine, First Affiliated Hospital, Department of Nursing, Haerbin, Heilongjiang, China.
Heilongjiang University of Chinese Medicine, First Affiliated Hospital, Department of Oncology, Haerbin, Heilongjiang, 150040, China.
J Med Biochem. 2025 Aug 21;44(5):955-964. doi: 10.5937/jomb0-56918.
To analyse the influence of Traditional Chinese Medicine (TCM)-characteristic rehabilitation management on T lymphocyte subsets, inflammatory response, and stress response during the postoperative chemotherapy of lung cancer (LC).
189 LC patients admitted to our hospital from July 2023 to June 2024 were enrolled in this research. Among them, 107 patients who did not receive TCM-characteristic rehabilitation management were regarded as the control group, while the other 82 patients who underwent such management were designated as the observation group. The levels of inflammatory factors and stress response markers before and after treatment in both groups were compared, including hypersensitive-C reactive protein (hs-CRP), interleukin-6 (IL-6), superoxide dismutase (SOD), malondialdehyde (MDA), and glutathione peroxidase (GSH-Px). The T lymphocyte subsets [CD3+, CD4+, CD8+, and natural killer (NK) cells] and gastrointestinal function were also detected.
After the completion of treatment, it was observed that the levels of hs-CRP MDA, and the proportion of CD8+ T lymphocyte subsets in the observation group were significantly reduced compared with the control group (P< 0.05). In contrast, the activities of SOD and GSH-Px, the proportions of CD3+ and CD4+ T lymphocyte subsets, as well as the activity of NK cells in the observation group were notably higher versus the control group (P< 0.05). Moreover, the gastrointestinal function of the patients in the observation group exhibited a more favourable condition after treatment (P< 0.05).
TCM-characteristic rehabilitation management can effectively ameliorate inflammatory responses and stress injury in patients undergoing postoperative chemotherapy for LC and enhance their immune and gastrointestinal functions.
分析中医特色康复管理对肺癌（LC）术后化疗期间T淋巴细胞亚群、炎症反应及应激反应的影响。
选取2023年7月至2024年6月我院收治的189例LC患者。其中，107例未接受中医特色康复管理的患者作为对照组，另外82例接受该管理的患者作为观察组。比较两组治疗前后炎症因子和应激反应标志物水平，包括超敏C反应蛋白（hs-CRP）、白细胞介素-6（IL-6）、超氧化物歧化酶（SOD）、丙二醛（MDA）和谷胱甘肽过氧化物酶（GSH-Px）。还检测了T淋巴细胞亚群[CD3+、CD4+、CD8+和自然杀伤（NK）细胞]及胃肠功能。
治疗结束后，观察到观察组hs-CRP、MDA水平及CD8+T淋巴细胞亚群比例较对照组显著降低（P<0.05）。相比之下，观察组SOD和GSH-Px活性、CD3+和CD4+T淋巴细胞亚群比例以及NK细胞活性显著高于对照组（P<0.05）。此外，观察组患者治疗后胃肠功能状况更佳（P<0.05）。
中医特色康复管理可有效改善LC术后化疗患者的炎症反应和应激损伤，增强其免疫和胃肠功能。
