Jia Wanyu, Sun Ruiyang, Hou Jiapu, Ding Zewen, Li Peng, Song Chunlan
Henan Province Engineering Research Center of Diagnosis and Treatment of Pediatric Infection and Critical Care, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, No. 1, South University Road, Erqi District, Zhengzhou, 450018, Henan, China.
Eur J Clin Microbiol Infect Dis. 2025 Sep 15. doi: 10.1007/s10096-025-05255-w.
The purpose was to validate the applicability of the Phoenix Sepsis Score and to compare it with other scores. The applicability of the Phoenix Sepsis Score in children with different primary statuses and age groups was compared. This study is a retrospective study. Children aged between 1 month and 18 years with a clinically suspected diagnosis of sepsis from January 2020 to December 2024 were selected for the study. Clinical data were collected and Phoenix Sepsis Score, paediatric Sequential Organ Failure Assessment, and Pediatric Logistic Organ Dysfunction Score-2 scores were calculated. The predictive values were assessed using the receiver operator characteristic curve. Compare the area under the curve of different receiver operator characteristic curves. A total of 341 children were included, of which 203 were Male, with a median age of 32 months. There were 103 children with primary diseases. Based on the Phoenix Sepsis Score, 174patients were diagnosed with sepsis. All three scores were significantly higher in the death group. The areas under the curve of the Phoenix Sepsis Score, paediatric Sequential Organ Failure Assessment and Pediatric Logistic Organ Dysfunction Score-2 scores for death in children with suspected sepsis were 0.874(0.834,0.907), 0.884(0.846,0.923) and 0.867(0.826,0.901), respectively. There were no statistically significant differences between the three scores in terms of predictive value. The area under the curve of Phoenix Sepsis Score for death in all age groups from 1 month to 11 years old were greater than 0.808(0.700,0.890). The areas under the curve of the Phoenix Sepsis Score for death in children with or without primary diseases were 0.790(0.699,0.864) and 0.894(0.839,0.949), respectively. The Phoenix Sepsis Score, paediatric Sequential Organ Failure Assessment and Pediatric Logistic Organ Dysfunction Score-2 scores had high predictive value for mortality in children with suspected sepsis. The Phoenix Sepsis Score had good predictive value in children at different primary states and different age. The predictive value of the Phoenix Sepsis Score was lower in children with primary disease.
目的是验证凤凰脓毒症评分的适用性,并将其与其他评分进行比较。比较了凤凰脓毒症评分在不同初始状态和年龄组儿童中的适用性。本研究为回顾性研究。选取2020年1月至2024年12月临床疑似脓毒症诊断的1个月至18岁儿童进行研究。收集临床数据并计算凤凰脓毒症评分、儿科序贯器官衰竭评估和儿科逻辑器官功能障碍评分-2。使用受试者工作特征曲线评估预测值。比较不同受试者工作特征曲线的曲线下面积。共纳入341名儿童,其中男性203名,中位年龄为32个月。有103名患有原发性疾病的儿童。根据凤凰脓毒症评分,174例患者被诊断为脓毒症。死亡组中所有三项评分均显著更高。疑似脓毒症儿童死亡的凤凰脓毒症评分、儿科序贯器官衰竭评估和儿科逻辑器官功能障碍评分-2的曲线下面积分别为0.874(0.834,0.907)、0.884(0.846,0.923)和0.867(0.826,0.901)。三项评分在预测值方面无统计学显著差异。1个月至11岁所有年龄组儿童死亡的凤凰脓毒症评分曲线下面积均大于0.808(0.700,0.890)。有或无原发性疾病儿童死亡的凤凰脓毒症评分曲线下面积分别为0.790(0.699,0.864)和0.894(0.839,0.949)。凤凰脓毒症评分、儿科序贯器官衰竭评估和儿科逻辑器官功能障碍评分-2对疑似脓毒症儿童的死亡率具有较高的预测价值。凤凰脓毒症评分在不同初始状态和不同年龄的儿童中具有良好的预测价值。凤凰脓毒症评分在患有原发性疾病的儿童中的预测价值较低。