Hanly J G, McKenna M J, Quigley C, Freaney R, Muldowney F P, FitzGerald M X
Q J Med. 1985 Jul;56(219):377-85.
This study reports serum 25-hydroxy vitamin D (25-(OH)D) levels, bone mineral content and bone maturation in 20 adolescent and adult patients with cystic fibrosis, and their response to the internationally recommended dose of supplementary vitamin D (800 iu/day; 20 micrograms/day). Serum 25-(OH)D values were below normal in 75 per cent of patients and serum alkaline phosphatase values, corrected for age, were increased in 60 per cent. Bone mineral content, measured by photon beam absorptiometry, was below the normal range in 45 per cent of patients and bone age retarded in 45 per cent. Following supplementation with vitamin D 40 per cent of patients failed to achieve normal serum 25-(OH)D levels. We concluded that hypovitaminosis D occurs frequently in older patients with cystic fibrosis and is accompanied by osteopenia and retarded bone maturation.
本研究报告了20例青少年及成年囊性纤维化患者的血清25-羟基维生素D（25-(OH)D）水平、骨矿物质含量和骨骼成熟情况，以及他们对国际推荐剂量补充维生素D（800国际单位/天；20微克/天）的反应。75%的患者血清25-(OH)D值低于正常水平，60%经年龄校正后的血清碱性磷酸酶值升高。通过光子束吸收法测量，45%的患者骨矿物质含量低于正常范围，45%的患者骨龄延迟。补充维生素D后，40%的患者未能达到正常血清25-(OH)D水平。我们得出结论，维生素D缺乏症在老年囊性纤维化患者中频繁发生，并伴有骨质减少和骨骼成熟延迟。
