Darbinyan L V, Hambardzumyan L E, Manukyan L P, Danielyan M H, Karapetyan K V, Sarkisian V H, Simonyan K V
Sensorimotor Integration Lab, Orbeli Institute of Physiology NAS RA, Yerevan, 0028, Armenia.
Histochemistry and Morphology Lab, Orbeli Institute of Physiology NAS RA, Yerevan, 0028, Armenia.
Metab Brain Dis. 2025 Sep 15;40(7):267. doi: 10.1007/s11011-025-01698-4.
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by degeneration of dopaminergic neurons, leading to motor impairments (bradykinesia, rigidity, tremor) and non-motor symptoms (cognitive decline, psychiatric disturbances). This study investigated the neuroprotective effects of curcumin in a rotenone-induced PD rat model. Male albino rats received daily intraperitoneal injections of rotenone (2 mg/kg) and/or curcumin (200 mg/kg) for 9 weeks. Behavioral assessments revealed that curcumin treatment significantly improved motor function, reducing catalepsy duration and increasing rearing frequency in cylinder tests. Histological analysis showed curcumin preserved neuronal density in both hippocampal and pedunculopontine nucleus (PPN) regions. Electrophysiological recordings showed that that curcumin modulated hippocampal responses to PPN high-frequency stimulation (100 Hz). These results suggest curcumin exerts multimodal neuroprotection by preserving neuronal integrity and stabilizing hippocampal-PPN circuitry. While our findings highlight curcumin's therapeutic potential, further studies quantifying synaptic markers and direct LTP measurements are needed to fully elucidate its effects on synaptic plasticity.
帕金森病（PD）是一种进行性神经退行性疾病，其特征是多巴胺能神经元变性，导致运动障碍（运动迟缓、僵硬、震颤）和非运动症状（认知衰退、精神障碍）。本研究在鱼藤酮诱导的PD大鼠模型中研究了姜黄素的神经保护作用。雄性白化大鼠连续9周每天腹腔注射鱼藤酮（2mg/kg）和/或姜黄素（200mg/kg）。行为评估显示，姜黄素治疗显著改善了运动功能，减少了僵住持续时间，并增加了圆筒试验中的竖毛频率。组织学分析表明，姜黄素保留了海马和脚桥核（PPN）区域的神经元密度。电生理记录表明，姜黄素调节了海马对PPN高频刺激（100Hz）的反应。这些结果表明，姜黄素通过维持神经元完整性和稳定海马-PPN回路发挥多模式神经保护作用。虽然我们的研究结果突出了姜黄素的治疗潜力，但需要进一步研究来量化突触标记物并进行直接的长时程增强测量，以充分阐明其对突触可塑性的影响。
