Prabhu N, Rajinikanth V, Narayanan Mathiyazhagan
Center for Research and Innovations, Department of Biotechnology, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, SIMATS, Thandalam, Chennai, 602 105, Tamil Nadu, India.
Med Oncol. 2025 Sep 15;42(11):473. doi: 10.1007/s12032-025-03033-4.
Pancreatic cancer is one of the most lethal tumors, marked by a dismal prognosis, few treatment alternatives, and resistance to standard pharmacological interventions. Marine algae are becoming a source of bioactive chemicals with significant anticancer properties. This review examines fucoidan, a sulfated polysaccharide, and phlorotannins, polyphenols exclusive to brown algae, emphasizing their therapeutic effects and molecular mechanisms in pancreatic cancer. Fucoidan inhibits tumor proliferation, promotes apoptosis, regulates immune responses, and prevents metastasis via pathways including PI3K/Akt, MAPK, and NF-κB. Phlorotannins demonstrate antioxidant, anti-inflammatory, and anti-epithelial-mesenchymal transition properties while inhibiting oncogenic signaling. Investigations on synergistic interactions with chemotherapeutics and nanodelivery methods that improve bioavailability are conducted. The discussion encompasses toxicological characteristics, pharmacokinetics, and existing research gaps to tackle translational issues. These discoveries collectively highlight the potential of marine algae chemicals as adjunctive approaches in pancreatic cancer treatment and stress the necessity for additional preclinical and clinical research.
胰腺癌是最致命的肿瘤之一，其特点是预后不佳、治疗选择有限且对标准药物干预具有抗性。海藻正成为具有显著抗癌特性的生物活性化学物质的来源。本综述探讨了岩藻聚糖（一种硫酸化多糖）和褐藻独有的多酚类物质——间苯三酚鞣质，重点阐述了它们在胰腺癌中的治疗作用及分子机制。岩藻聚糖通过包括PI3K/Akt、MAPK和NF-κB在内的信号通路抑制肿瘤增殖、促进细胞凋亡、调节免疫反应并防止转移。间苯三酚鞣质具有抗氧化、抗炎和抗上皮-间质转化特性，同时抑制致癌信号传导。还对其与化疗药物的协同相互作用以及提高生物利用度的纳米递送方法进行了研究。讨论内容包括毒理学特征、药代动力学以及解决转化问题的现有研究空白。这些发现共同凸显了海藻化学物质作为胰腺癌辅助治疗方法的潜力，并强调了进一步开展临床前和临床研究的必要性。
