Devaraji Mahalakshmi, Thanikachalam Punniyakoti V
Department of Pharmaceutical Chemistry, Saveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, 602105, India.
Cancer Pathog Ther. 2025 Feb 28;3(5):364-382. doi: 10.1016/j.cpt.2025.02.006. eCollection 2025 Sep.
Breast cancer remains one of the leading causes of cancer-related morbidity and mortality among women worldwide, necessitating the development of novel therapeutic strategies. Phytoconstituents, naturally plant-derived bioactive compounds, have emerged as promising agents for breast cancer therapy due to their multifaceted mechanisms of action. This review examines the role of phytoconstituents in inducing apoptosis, inhibiting breast cancer cell proliferation, and suppressing metastasis. Furthermore, the anti-angiogenic effects of these compounds are discussed, highlighting their potential to disrupt tumor vascularization. We also summarize the in vitro and in vivo study-derived preclinical evidence supporting the efficacy of phytoconstituents. The synergistic potential of phytoconstituents with conventional therapies is also explored, emphasizing their ability to enhance treatment efficacy while minimizing adverse effects. We also address the challenges and limitations in the clinical application of phytoconstituents, paving the way for future research. This review provides insights into the therapeutic potential of phytoconstituents in breast cancer and their underlying mechanisms, advocating for their integration into existing treatment regimens.
乳腺癌仍然是全球女性癌症相关发病和死亡的主要原因之一，因此需要开发新的治疗策略。植物成分，即天然植物衍生的生物活性化合物，由于其多方面的作用机制，已成为乳腺癌治疗的有前景的药物。本综述探讨了植物成分在诱导细胞凋亡、抑制乳腺癌细胞增殖和抑制转移方面的作用。此外，还讨论了这些化合物的抗血管生成作用，突出了它们破坏肿瘤血管生成的潜力。我们还总结了支持植物成分疗效的临床前证据，这些证据来自体外和体内研究。还探讨了植物成分与传统疗法的协同潜力，强调了它们在提高治疗效果的同时将不良反应降至最低的能力。我们还讨论了植物成分临床应用中的挑战和局限性，为未来的研究铺平道路。本综述深入探讨了植物成分在乳腺癌治疗中的潜力及其潜在机制，主张将其纳入现有治疗方案。
