Güneşli Aylin, Keskin Ahmet Onur
Department of Radiology, Adana Teaching and Research Center, Baskent University, Dadaloğlu Mahallesi, 2591 sokak. No: 4/A, Adana, Yüreğir, 01250, Turkey.
School of Medicine, Department of Neurology, Sağlık Bilimleri University, Eskişehir, Turkey.
Neurol Sci. 2025 Sep 15. doi: 10.1007/s10072-025-08464-5.
The aim of the study was to investigate whether atherosclerosis and cardiovascular disease risk are elevated in patients with migraine. To this end, epicardial fat, carotid intima-media thickness, carotid distensibility, and strain were measured and compared between migraine patients and healthy volunteers.
The study was designed as a cross-sectional. A total of 174 patients (103 migraine without aura and 71 migraine with aura) and 91 healthy volunteers were included. The study evaluated whether there were significant differences between the groups in epicardial fat, carotid intima-media thickness, carotid distensibility and strain, and examined their correlations with disease duration and headache days per month.
Epicardial fat, carotid intima-media thickness, distensibility, and strain differed significantly among the three groups ( p = 0.006, p = 0.011, p = 0.006 and p = 0.023 respectively). Both migraine groups (with and without aura) showed significant differences in epicardial fat thickness and carotid distensibility compared to controls ( p = 0.002, p = 0.028 and p = 0.043, p = 0.008 respectivly). Carotid intima-media thickness and strain were significantly different only between the migraine without aura group and controls ( p = 0.02 and p = 0.025 respectively), with no significant difference observed for the migraine with aura group ( p = 0.883 and p = 0.184 respectively). In both migraine groups, these vascular parameters were significantly correlated with disease duration and headache days per month (p < 0.05).
The study findings suggest that patients diagnosed with migraine may exhibit early signs of subclinical atherosclerosis. This increased risk appears to be more closely associated with the duration and severity of the disease, rather than the presence of aura.
本研究旨在调查偏头痛患者的动脉粥样硬化和心血管疾病风险是否升高。为此，测量并比较了偏头痛患者和健康志愿者的心外膜脂肪、颈动脉内膜中层厚度、颈动脉扩张性和应变。
本研究设计为横断面研究。共纳入174例患者（103例无先兆偏头痛患者和71例有先兆偏头痛患者）和91例健康志愿者。该研究评估了各组在心外膜脂肪、颈动脉内膜中层厚度、颈动脉扩张性和应变方面是否存在显著差异，并检查了它们与疾病持续时间和每月头痛天数的相关性。
三组在心外膜脂肪、颈动脉内膜中层厚度、扩张性和应变方面存在显著差异（分别为p = 0.006、p = 0.011、p = 0.006和p = 0.023）。与对照组相比，两个偏头痛组（有先兆和无先兆）在心外膜脂肪厚度和颈动脉扩张性方面均存在显著差异（分别为p = 0.002、p = 0.028和p = 0.043、p = 0.008）。颈动脉内膜中层厚度和应变仅在无先兆偏头痛组与对照组之间存在显著差异（分别为p = 0.02和p = 0.025），有先兆偏头痛组未观察到显著差异（分别为p = 0.883和p = 0.184）。在两个偏头痛组中，这些血管参数均与疾病持续时间和每月头痛天数显著相关（p < 0.05）。
研究结果表明，被诊断为偏头痛的患者可能表现出亚临床动脉粥样硬化的早期迹象。这种增加的风险似乎与疾病的持续时间和严重程度更密切相关，而不是与先兆的存在有关。
