Amrollahi Narjes, Tarrahi Mohammad Javad, Abbasi Zahra
Assistant Professor. Dental Research Center, Department of Pediatric Dentistry, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Epidemiology and Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran.
Saudi Dent J. 2024 Dec;36(12):1495-1502. doi: 10.1016/j.sdentj.2024.11.009. Epub 2024 Dec 9.
Chronic kidney disease (CKD) is a disorder that causes numerous problems for children and affects many organs, as oral hard and soft tissues. The purpose of this study was to summarize the relationship between oral and dental health status and CKD in children.
A systematic search of texts from 2000 to 2023 was conducted to gather all case control studies published in the English language related to the subject of this study in PubMed, Web of Science, Scopus and Cochrane electronic databases. The title, abstract and full text of the articles were examined according to inclusion criteria until relevant studies were selected. This process was carried out independently by two researchers. The quality of the selected studies was assessed by the National Institutes of Health (NIH) checklist.
A total of 768 articles were identified in electronic databases during the search process. Articles inconsistent with inclusion criteria and duplicate articles were removed and 8 studies were selected for -analysis. The results found no statistically significant difference in mean of decayed, missing and filled teeth in permanent (DMFT index) and primary teeth (dmft index) in CKD and healthy children with a mean difference of -0.433 (95 % CI: -1.689 to 0.823; p-value = 0.500) and-0.095 (95 % CI: -2.240 to 2.051; p-value = 0.931) respectively. However, CKD had a significant effect on the developmental defects of enamel (DDE) index in children with an effect size of 4.916 (95 % CI: 1.752 to 13.799; p-value = 0.002).
The presence of CKD can increase the incidence of DDE by 4.9 times, but it has no significant effect on the prevalence of dental caries in primary and permanent teeth.
慢性肾脏病（CKD）是一种给儿童带来诸多问题且影响多个器官的疾病，口腔软硬组织也会受到影响。本研究的目的是总结儿童口腔和牙齿健康状况与CKD之间的关系。
对2000年至2023年的文献进行系统检索，以收集在PubMed、科学网、Scopus和Cochrane电子数据库中发表的所有与本研究主题相关的英文病例对照研究。根据纳入标准对文章的标题、摘要和全文进行审查，直至选定相关研究。此过程由两名研究人员独立进行。所选研究的质量通过美国国立卫生研究院（NIH）清单进行评估。
在检索过程中，电子数据库共识别出768篇文章。剔除不符合纳入标准的文章和重复文章后，选择8项研究进行分析。结果发现，CKD患儿与健康儿童的恒牙龋失补牙面均值（DMFT指数）和乳牙龋失补牙面均值（dmft指数）无统计学显著差异，平均差值分别为-0.433（95%置信区间：-1.689至0.823；p值=0.500）和-0.095（95%置信区间：-2.240至2.051；p值=0.931）。然而，CKD对儿童釉质发育缺陷（DDE）指数有显著影响，效应大小为4.916（95%置信区间：1.752至13.799；p值=0.002）。
CKD的存在可使DDE的发生率增加4.9倍，但对乳牙和恒牙的龋齿患病率无显著影响。
