Czernichow P, Caillard J F, Prudent P, Bastard C, Proust B
Rev Epidemiol Sante Publique. 1985;33(4-5):292-6.
A sero-epidemiologic survey about risk of hepatitis was conducted with antibody to hepatitis B core antigen in a large hospital between 1981 and 1984. Among 2363 volunteers for vaccine in health care personnel, 285 were sero-positive (12.0%). Seropositivity increases with age and duration of employment in hospital. It is also associated with occupational category and hospital sector of activity. Using logistic regression method for analysis of risk factors, duration of employment was found as being the predominant one. Other factors included in the model were activity in pediatric wards, health care schools, intensive care units, surgical wards, medical staff and paramedics (low risk), surgeons, anesthetists and laboratory housekeepers (high risk). Nevertheless, operational target group for vaccine cannot be clearly defined. It was concluded that indications for vaccine should be extended to all health care hospital personnel.
1981年至1984年期间,在一家大型医院针对乙肝核心抗原抗体开展了一项关于肝炎风险的血清流行病学调查。在2363名医护人员疫苗接种志愿者中,285人血清呈阳性(12.0%)。血清阳性率随年龄和在医院的工作年限增加而升高。它还与职业类别和医院活动科室有关。采用逻辑回归方法分析风险因素,发现工作年限是主要因素。模型中纳入的其他因素包括在儿科病房、医护学校、重症监护病房、外科病房工作,医务人员和护理人员(低风险),外科医生、麻醉师和实验室管理员(高风险)。然而,疫苗接种的操作目标人群尚无法明确界定。得出的结论是,疫苗接种适应证应扩大到所有医院医护人员。