新生儿急性肾损伤的定义：完美的定义是否可实现甚至是否可取？第一届国际新生儿肾脏病研讨会会议记录。
Neonatal AKI Definition: Is the perfect definition attainable or even desirable? Proceedings from the First International Neonatal Nephrology Symposium.
作者信息
Beck Tara, Isaac Jaya, Deutmeyer Miranda, Starr Michelle C, Slagle Cara, Askenazi David J, Goldstein Stuart L, Selewski David T
机构信息
University of Pittsburgh School of Medicine UPMC Pittsburgh Children's Hospital Pittsburgh, Pittsburgh, PA, USA.
Division of Pediatric Nephrology, Department of Pediatrics, Children's Hospital at Montefiore/Einstein, Bronx, NY, USA.
出版信息
Pediatr Res. 2025 Sep 15. doi: 10.1038/s41390-025-04400-7.
The consensus neonatal modified KDIGO definition has been crucial in expanding our understanding of the epidemiology and impact of neonatal AKI. A consensus definition of neonatal AKI remains essential to continuing to advance the field. This manuscript highlights a historical perspective, the strengths, and limitations of the current neonatal AKI definition, and reflects on the optimal characteristics and utility of neonatal AKI definitions. The future of neonatal AKI lies with improved diagnostic precision and consistently incorporating neonatal risk factors into risk stratification incorporating and the deployment of novel biomarkers to aid in earlier identification and improve outcomes in neonatal AKI.
新生儿KDIGO改良共识定义对于拓展我们对新生儿急性肾损伤（AKI）流行病学及影响的理解至关重要。新生儿AKI的共识定义对于该领域的持续发展仍然必不可少。本文着重介绍了历史观点、当前新生儿AKI定义的优势与局限性，并思考了新生儿AKI定义的最佳特征及实用性。新生儿AKI的未来在于提高诊断精度，持续将新生儿风险因素纳入风险分层，并应用新型生物标志物以助于早期识别并改善新生儿AKI的预后。
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