• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Electrochemical synthesis of spirooxindole-pyranopyrazole and spirooxindole-chromene derivatives as inhibitors of acetylcholinesterase.

作者信息

Elsapagh Reem M, Osman Eman O, Hafez Ahmed M, El-Nassan Hala B

机构信息

Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, 33 Kasr El-Aini street, Cairo, 11562, Egypt.

Department of Biochemistry, School of Life and Medical Sciences, University of Hertfordshire Hosted by Global Academic Foundation, Cairo, 11586, Egypt.

出版信息

BMC Chem. 2025 Sep 15;19(1):260. doi: 10.1186/s13065-025-01618-8.

DOI:10.1186/s13065-025-01618-8
PMID:40954498
Abstract
摘要

相似文献

1
Electrochemical synthesis of spirooxindole-pyranopyrazole and spirooxindole-chromene derivatives as inhibitors of acetylcholinesterase.作为乙酰胆碱酯酶抑制剂的螺环氧化吲哚 - 吡喃并吡唑和螺环氧化吲哚 - 色烯衍生物的电化学合成。
BMC Chem. 2025 Sep 15;19(1):260. doi: 10.1186/s13065-025-01618-8.
2
Unveiling the anticancer potential of novel spirooxindole-tethered pyrazolopyridine derivatives.揭示新型螺环氧化吲哚连接的吡唑并吡啶衍生物的抗癌潜力。
Bioorg Chem. 2024 Dec;153:107778. doi: 10.1016/j.bioorg.2024.107778. Epub 2024 Aug 31.
3
Design, synthesis, and pharmacological evaluation of heteroaryl thiol-linked kojic acid derivatives as a novel class of acetylcholinesterase inhibitors for Alzheimer's disease therapy.作为用于阿尔茨海默病治疗的新型乙酰胆碱酯酶抑制剂的杂芳基硫醇连接的曲酸衍生物的设计、合成及药理学评价
3 Biotech. 2025 May;15(5):134. doi: 10.1007/s13205-025-04295-5. Epub 2025 Apr 18.
4
From Bench to Bioactivity: Pyranopyrazole Synthesis, Anticancer, Antimicrobial Efficacy, DFT, Molecular Docking, and Molecular Dynamic Insights.从实验台到生物活性：吡喃并吡唑的合成、抗癌、抗菌功效、密度泛函理论、分子对接及分子动力学见解
Anticancer Agents Med Chem. 2025;25(16):1253-1271. doi: 10.2174/0118715206376210250319053528.
5
Synthesis and in Silico Study of Novel Benzisoxazole-Chromene Derivatives as Potent Inhibitors of Acetylcholinesterase: Metal-Free Site-Selective C-N Bond Formation via Aza-Michael Reaction.新型苯并恶唑-色烯衍生物的合成及计算机研究作为乙酰胆碱酯酶的有效抑制剂：通过氮杂迈克尔反应实现无金属的位点选择性 C-N 键形成。
Chem Biodivers. 2023 Aug;20(8):e202300573. doi: 10.1002/cbdv.202300573. Epub 2023 Jul 20.
6
Design, Synthesis, and Evaluation of 1-Benzylpiperidine and 1-Benzoylpiperidine Derivatives as Dual-Target Inhibitors of Acetylcholinesterase and Serotonin Transporter for Alzheimer's Disease.作为阿尔茨海默病乙酰胆碱酯酶和血清素转运体双靶点抑制剂的1-苄基哌啶和1-苯甲酰基哌啶衍生物的设计、合成与评价
Molecules. 2025 Jul 21;30(14):3047. doi: 10.3390/molecules30143047.
7
Novel 2-Alkoxy-3-Cyanopyridine Derivatives as Cholinesterase Inhibitors: Synthesis, Biological Evaluation, and In Silico Investigations.新型2-烷氧基-3-氰基吡啶衍生物作为胆碱酯酶抑制剂：合成、生物学评价及计算机模拟研究
Chem Biodivers. 2025 Jul;22(7):e202402915. doi: 10.1002/cbdv.202402915. Epub 2025 Mar 23.
8
In silico studies and in vitro evaluation of isatin-pyridine oxime hybrids as novel reactivators of acetylcholinesterase inhibited by an A-230 surrogate.异吲哚酮-吡啶肟杂化物作为A-230替代物抑制的乙酰胆碱酯酶新型重活化剂的计算机模拟研究和体外评价
Arch Toxicol. 2025 May;99(5):2225-2228. doi: 10.1007/s00204-025-03976-7. Epub 2025 Mar 4.
9
Synthesis, insecticidal activity against Aedes aegypti and acetylcholinesterase inhibition of new N-arylmethyl-1,2,3,4-tetrahydroquinoline derivatives containing an N-arylmethylpiperidine scaffold inspired on donepezil structure.基于多奈哌齐结构设计的含N-芳基甲基哌啶骨架的新型N-芳基甲基-1,2,3,4-四氢喹啉衍生物的合成、对埃及伊蚊的杀虫活性及乙酰胆碱酯酶抑制作用
Bioorg Chem. 2025 Sep;164:108816. doi: 10.1016/j.bioorg.2025.108816. Epub 2025 Jul 29.
10
In Silico Study, Synthesis, and In Vitro Evaluation of Acetylcholinesterase and Butyrylcholinesterase Inhibitory Activity of Novel N-Thiazole Substituted Acetamide Coumarin Derivatives.新型N-噻唑取代乙酰胺香豆素衍生物对乙酰胆碱酯酶和丁酰胆碱酯酶抑制活性的计算机模拟研究、合成及体外评价
Chem Biodivers. 2025 Jun;22(6):e202401524. doi: 10.1002/cbdv.202401524. Epub 2025 Feb 4.

本文引用的文献

1
Natural Inhibitors of MDR Efflux Pumps AcrAB and AcrD: An Integrated In Silico, Molecular, and In Vitro Investigation.多药耐药外排泵AcrAB和AcrD的天然抑制剂：计算机模拟、分子和体外综合研究
Int J Mol Sci. 2024 Dec 2;25(23):12949. doi: 10.3390/ijms252312949.
2
Green electrosynthesis of bis(indolyl)methane derivatives in deep eutectic solvents.在深共熔溶剂中双（吲哚基）甲烷衍生物的绿色电合成
BMC Chem. 2024 Jul 27;18(1):139. doi: 10.1186/s13065-024-01245-9.
3
Synthesis of Tetrahydro-β-carboline Derivatives under Electrochemical Conditions in Deep Eutectic Solvents.
在深共熔溶剂中电化学条件下四氢-β-咔啉衍生物的合成
ACS Omega. 2024 Mar 14;9(12):14198-14209. doi: 10.1021/acsomega.3c09790. eCollection 2024 Mar 26.
4
The anti-Alzheimer potential of novel spiroindolin-1,2-diazepine derivatives as targeted cholinesterase inhibitors with modified substituents.新型螺环吲哚啉-1,2-二氮杂卓衍生物作为靶向乙酰胆碱酯酶抑制剂的抗阿尔茨海默病潜力，其取代基经过修饰。
Sci Rep. 2023 Jul 24;13(1):11952. doi: 10.1038/s41598-023-38236-0.
5
Butyrylcholinesterase in lipid metabolism: A new outlook.酰基胆碱酯酶在脂代谢中的作用：新视角。
J Neurochem. 2024 Apr;168(4):381-385. doi: 10.1111/jnc.15833. Epub 2023 May 11.
6
Spirooxindole: A Versatile Biologically Active Heterocyclic Scaffold.螺噁嗪吲哚：一种多功能的生物活性杂环支架。
Molecules. 2023 Jan 7;28(2):618. doi: 10.3390/molecules28020618.
7
Synthesis, kinetic evaluation and molecular docking studies of donepezil-based acetylcholinesterase inhibitors.多奈哌齐基乙酰胆碱酯酶抑制剂的合成、动力学评估及分子对接研究
J Mol Struct. 2022 Jan 5;1247. doi: 10.1016/j.molstruc.2021.131425. Epub 2021 Sep 3.
8
Construction of Spirooxindole Analogues Engrafted with Indole and Pyrazole Scaffolds as Acetylcholinesterase Inhibitors.以吲哚和吡唑为骨架的螺氧化吲哚类似物作为乙酰胆碱酯酶抑制剂的构建。
ACS Omega. 2021 Nov 12;6(47):31539-31556. doi: 10.1021/acsomega.1c03978. eCollection 2021 Nov 30.
9
Acetylcholinesterase Inhibitors in the Treatment of Neurodegenerative Diseases and the Role of Acetylcholinesterase in their Pathogenesis.乙酰胆碱酯酶抑制剂在神经退行性疾病治疗中的作用及其在发病机制中的作用。
Int J Mol Sci. 2021 Aug 27;22(17):9290. doi: 10.3390/ijms22179290.
10
Spectral, thermal, antimicrobial studies for silver(I) complexes of pyrazolone derivatives.吡唑啉酮衍生物银（I）配合物的光谱、热学及抗菌研究
BMC Chem. 2020 Dec 5;14(1):69. doi: 10.1186/s13065-020-00723-0.