Aitasalo K, Lehtinen R
Scand J Plast Reconstr Surg. 1985;19(3):237-44. doi: 10.3109/02844318509074509.
The influence of periosteal transplants on irradiated bone cavities was studied in ten adult rabbit hind legs. The left hind legs were irradiated with a single X-ray dose of 20 Gy one week before operation. The right hind leg was used as a control. Radiological, histological and biochemical findings were recorded for specimens obtained 8 and 12 weeks after operation. Non-irradiated periosteal transplants on irradiated bone cavities induced more rapid and intense mature bone formation than irradiated periosteal transplants on the same areas. Ossification of bone cavities occurred even more rapidly, when neither the bone nor the transplant had been irradiated. These results indicate that a free periosteal transplant enhances ossification on irradiated bone cavities, whereas ossification may be inhibited or delayed after radiation therapy. A similar effect on diseased human mandibular bone has been observed in our clinical trials.
在十只成年兔的后腿上研究了骨膜移植对受照射骨腔的影响。在手术前一周，对左后腿进行单次20 Gy的X射线照射。右后腿用作对照。记录术后8周和12周获得的标本的放射学、组织学和生化结果。在受照射的骨腔上移植未受照射的骨膜比在相同区域移植受照射的骨膜能诱导更快、更强烈的成熟骨形成。当骨和移植组织都未受照射时，骨腔的骨化发生得更快。这些结果表明，游离骨膜移植可增强受照射骨腔的骨化，而放射治疗后骨化可能受到抑制或延迟。在我们的临床试验中，已观察到对人类患病下颌骨有类似的效果。
