Wang Lihui, Feng Lina, Ning Baicheng, Wang Zhuolin, Dai Chunmei, Li Mingquan
College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin Province, People's Republic of China.
Department of Neurology, The Third Affiliated Clinical Hospital of the Changchun University of Chinese Medicine, Changchun, Jilin Province, People's Republic of China.
Drug Des Devel Ther. 2025 Sep 10;19:8135-8159. doi: 10.2147/DDDT.S534706. eCollection 2025.
This review summarizes recent advances in leveraging natural products from Chinese medicine to modulate the nuclear factor kappa B (NF-κB) signaling pathway for the prevention and treatment of neurodegenerative diseases (NDDs), focusing specifically on Alzheimer's disease (AD), Parkinson's disease (PD), and Amyotrophic lateral sclerosis (ALS). NF-κB proteins regulate cellular biological activity by binding to promoter regions in the nucleus and transcribing various protein-coding genes. Emerging evidence indicates that NF-κB plays a pivotal role in driving key hallmarks of NDD progression, including neuroinflammation, oxidative stress, mitochondrial dysfunction, and dysregulation of the cell cycle. Natural products from Chinese medicine exert modulatory effects on NF-κB signaling through diverse pharmacological mechanisms, ultimately improving cognitive and motor impairments in preclinical NDDs models. The pleiotropic nature of natural products derived from traditional Chinese medicine (TCM)-which operate through subunit-specific modulation of NF-κB-underscores their potential as next-generation therapeutics. Investigating the intricate regulation of NF-κB by natural products from Chinese medicine will not only enrich our understanding of the pathogenesis of NDDs but also establish a theoretical foundation for the development of new therapeutic drugs for NDDs, providing innovative strategies for prevention and treatment.
本综述总结了利用中药天然产物调节核因子κB（NF-κB）信号通路以预防和治疗神经退行性疾病（NDDs）的最新进展，特别关注阿尔茨海默病（AD）、帕金森病（PD）和肌萎缩侧索硬化症（ALS）。NF-κB蛋白通过与细胞核中的启动子区域结合并转录各种蛋白质编码基因来调节细胞生物学活性。新出现的证据表明，NF-κB在驱动NDD进展的关键特征中起关键作用，包括神经炎症、氧化应激、线粒体功能障碍和细胞周期失调。中药天然产物通过多种药理机制对NF-κB信号产生调节作用，最终改善临床前NDDs模型中的认知和运动障碍。源自传统中药（TCM）的天然产物具有多效性，通过对NF-κB的亚基特异性调节发挥作用，突出了它们作为下一代治疗药物的潜力。研究中药天然产物对NF-κB的复杂调节不仅将丰富我们对NDDs发病机制的理解，还将为开发NDDs的新治疗药物奠定理论基础，为预防和治疗提供创新策略。
