Schröder-Heurich Bianca, Meyer Nadia, Richter Katja, von Kaisenberg Constantin S, von Versen-Höynck Frauke
Gynecology Research Unit, Hannover Medical School, Hannover, Germany.
Department of Obstetrics and Gynecology, Hannover Medical School, Hannover, Germany.
FASEB J. 2025 Sep 30;39(18):e71043. doi: 10.1096/fj.202502468R.
Preeclampsia is a serious pregnancy-related disorder that poses significant health risks to the mother and offspring. A key aspect of preeclampsia is impaired endothelial cell migration, which is essential for the repair and integrity of the vasculature. Preeclamptic endothelial progenitor cells (EPC) exhibit defects in migration, although the precise molecular mechanisms underlying these defects remain unclear. Cellular spatial organization, such as centrosome orientation, regulates the migration process by influencing cell polarity and movement. Epigenetic changes in preeclampsia may disrupt these processes and thus impair endothelial function. We recently described the role of microRNA (miR)-1270 in preeclamptic EPC, linking its dysregulated expression to impaired EPC motility. Here, we demonstrate that endothelial cell migration defects in preeclampsia, along with reduced miR-1270 levels, are accompanied by changes in centrosome orientation. This study provides novel insights into the molecular consequences of preeclampsia and its detrimental effects on endothelial dynamics.
子痫前期是一种与妊娠相关的严重疾病，对母亲和胎儿都构成重大健康风险。子痫前期的一个关键方面是内皮细胞迁移受损，而这对于血管系统的修复和完整性至关重要。子痫前期的内皮祖细胞（EPC）表现出迁移缺陷，尽管这些缺陷背后的确切分子机制仍不清楚。细胞的空间组织，如中心体方向，通过影响细胞极性和运动来调节迁移过程。子痫前期的表观遗传变化可能会破坏这些过程，从而损害内皮功能。我们最近描述了微小RNA（miR）-1270在子痫前期EPC中的作用，将其表达失调与EPC运动受损联系起来。在此，我们证明子痫前期的内皮细胞迁移缺陷以及miR-1270水平降低与中心体方向的变化有关。这项研究为子痫前期的分子后果及其对内皮动力学的有害影响提供了新的见解。
