[脑突触体膜制剂中5-羟色胺敏感性腺苷酸环化酶活性]
[5-hydroxytryptamine-sensitive adenylate cyclase activity in brain synaptosomal membrane preparations].
作者信息
Fillion G, Rousselle J C, Goiny M, Pradelles P, Dray F, Jacob J
出版信息
C R Acad Hebd Seances Acad Sci D. 1977 Jul 18;285(3):265-8.
A serotonine-sensitive adenylate cyclase system has been observed in horse brain membrane preparations. In crude mitochondrial fraction two types of activation sites were characterized, the Ka being = 2 nM and 1 micrometer. In purified synaptosomal membranes, a single adenylate cyclase activation was observed corresponding to the highest apparent affinity (KD = 2nM). This activation site might be related to the high affinity binding site (KD = 2NM) were previously described in the same membrane preparations.
在马脑细胞膜制剂中观察到一种对血清素敏感的腺苷酸环化酶系统。在粗线粒体部分，鉴定出两种类型的激活位点，其 Ka 分别为 2 nM 和 1 微米。在纯化的突触体膜中，观察到单一的腺苷酸环化酶激活，对应于最高的表观亲和力（KD = 2nM）。该激活位点可能与先前在相同膜制剂中描述的高亲和力结合位点（KD = 2NM）有关。
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